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• W1989621859 abstract "The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2(-/-) mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility." @default.
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• W1989621859 date "2014-01-01" @default.
• W1989621859 modified "2023-10-14" @default.
• W1989621859 title "Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm" @default.
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• W1989621859 doi "https://doi.org/10.1016/j.fob.2014.04.004" @default.
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