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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989627030> ?p ?o ?g. }

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• W1989627030 abstract "A new series of side-chain modified 4-aminoquinolines have been synthesized and found active against P. falciparum in vitro and P. yoelli in vivo. Compounds 6, 11, 12, and 19 exhibited superior in vitro activity compared to chloroquine. Selected compounds 6, 12, and 19 exhibited significant suppression in the in vivo assay. These analogs form a complex with hematin and inhibit the β-hematin formation, suggesting that this class of compounds act on a heme polymerization target." @default.
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• W1989627030 date "2006-12-29" @default.
• W1989627030 modified "2023-10-18" @default.
• W1989627030 title "Synthesis and Antimalarial Activity of Side Chain Modified 4-Aminoquinoline Derivatives" @default.
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• W1989627030 doi "https://doi.org/10.1021/jm061002i" @default.
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