FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989645441> ?p ?o ?g. }

• W1989645441 endingPage "201" @default.
• W1989645441 startingPage "192" @default.
• W1989645441 abstract "Purpose: To investigate the possible cytotoxic interactions between the chemotherapeutic drug temozolomide (TMZ) and the cyclooxygenase-2 inhibitor meloxicam (MLC) or of both drugs combined with X-rays in three human glioma cell lines (D384, Hs 683 and U251).Materials and methods: Cells were exposed to TMZ (96 hours) and MLC was co-incubated during the last 24 h. Thereafter, cells were irradiated with X-rays and plated for a clonogenic assay. Total cell numbers and the numbers of surviving cells were determined to study the recovery of the cell populations (up until 19 days) following different combinations of TMZ, MLC and X-rays.Results: The combination of MLC and TMZ caused an enhanced cytotoxic effect in D384 and Hs 683. Various treatment combinations demonstrated significant radiation enhancement in all three cell lines. Long-term observations of D384 cells demonstrated that the repopulation rates of the surviving cells are far less affected by the various treatment protocols than those from the non-surviving cells.Conclusions: The present study demonstrates that a combination of TMZ and MLC resulted in a significant potentiation of their cytotoxicity in D384 and Hs683. The combination of these two drugs can also cause considerable enhancement of the radiation response in human glioma cell lines, although only D384 cells benefit from trimodal over bimodal treatment." @default.
• W1989645441 created "2016-06-24" @default.
• W1989645441 creator A5015170911 @default.
• W1989645441 creator A5021334115 @default.
• W1989645441 creator A5038018657 @default.
• W1989645441 creator A5040476253 @default.
• W1989645441 date "2010-11-10" @default.
• W1989645441 modified "2023-09-27" @default.
• W1989645441 title "Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells" @default.
• W1989645441 cites W1872551000 @default.
• W1989645441 cites W1967090290 @default.
• W1989645441 cites W1969094967 @default.
• W1989645441 cites W1974339934 @default.
• W1989645441 cites W1994164930 @default.
• W1989645441 cites W1998232267 @default.
• W1989645441 cites W1999476677 @default.
• W1989645441 cites W2007696702 @default.
• W1989645441 cites W2017985800 @default.
• W1989645441 cites W2026408479 @default.
• W1989645441 cites W2034539919 @default.
• W1989645441 cites W2044376109 @default.
• W1989645441 cites W2049721139 @default.
• W1989645441 cites W2052083735 @default.
• W1989645441 cites W2074408983 @default.
• W1989645441 cites W2096287682 @default.
• W1989645441 cites W2099318069 @default.
• W1989645441 cites W2101364134 @default.
• W1989645441 cites W2105100844 @default.
• W1989645441 cites W2105372476 @default.
• W1989645441 cites W2109368764 @default.
• W1989645441 cites W2111420136 @default.
• W1989645441 cites W2114012083 @default.
• W1989645441 cites W2120872266 @default.
• W1989645441 cites W2122303312 @default.
• W1989645441 cites W2132834292 @default.
• W1989645441 cites W2133125477 @default.
• W1989645441 cites W2143995064 @default.
• W1989645441 cites W2146950362 @default.
• W1989645441 cites W2150922140 @default.
• W1989645441 cites W2161227192 @default.
• W1989645441 cites W2167426480 @default.
• W1989645441 cites W2276413550 @default.
• W1989645441 cites W2290575488 @default.
• W1989645441 doi "https://doi.org/10.3109/09553002.2010.519423" @default.
• W1989645441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21067299" @default.
• W1989645441 hasPublicationYear "2010" @default.
• W1989645441 type Work @default.
• W1989645441 sameAs 1989645441 @default.
• W1989645441 citedByCount "3" @default.
• W1989645441 countsByYear W19896454412023 @default.
• W1989645441 crossrefType "journal-article" @default.
• W1989645441 hasAuthorship W1989645441A5015170911 @default.
• W1989645441 hasAuthorship W1989645441A5021334115 @default.
• W1989645441 hasAuthorship W1989645441A5038018657 @default.
• W1989645441 hasAuthorship W1989645441A5040476253 @default.
• W1989645441 hasConcept C109316439 @default.
• W1989645441 hasConcept C117262875 @default.
• W1989645441 hasConcept C1491633281 @default.
• W1989645441 hasConcept C154317977 @default.
• W1989645441 hasConcept C185592680 @default.
• W1989645441 hasConcept C202751555 @default.
• W1989645441 hasConcept C2777389519 @default.
• W1989645441 hasConcept C2778227246 @default.
• W1989645441 hasConcept C2779751750 @default.
• W1989645441 hasConcept C502942594 @default.
• W1989645441 hasConcept C54355233 @default.
• W1989645441 hasConcept C71924100 @default.
• W1989645441 hasConcept C81885089 @default.
• W1989645441 hasConcept C86803240 @default.
• W1989645441 hasConcept C98274493 @default.
• W1989645441 hasConceptScore W1989645441C109316439 @default.
• W1989645441 hasConceptScore W1989645441C117262875 @default.
• W1989645441 hasConceptScore W1989645441C1491633281 @default.
• W1989645441 hasConceptScore W1989645441C154317977 @default.
• W1989645441 hasConceptScore W1989645441C185592680 @default.
• W1989645441 hasConceptScore W1989645441C202751555 @default.
• W1989645441 hasConceptScore W1989645441C2777389519 @default.
• W1989645441 hasConceptScore W1989645441C2778227246 @default.
• W1989645441 hasConceptScore W1989645441C2779751750 @default.
• W1989645441 hasConceptScore W1989645441C502942594 @default.
• W1989645441 hasConceptScore W1989645441C54355233 @default.
• W1989645441 hasConceptScore W1989645441C71924100 @default.
• W1989645441 hasConceptScore W1989645441C81885089 @default.
• W1989645441 hasConceptScore W1989645441C86803240 @default.
• W1989645441 hasConceptScore W1989645441C98274493 @default.
• W1989645441 hasIssue "2" @default.
• W1989645441 hasLocation W19896454411 @default.
• W1989645441 hasLocation W19896454412 @default.
• W1989645441 hasOpenAccess W1989645441 @default.
• W1989645441 hasPrimaryLocation W19896454411 @default.
• W1989645441 hasRelatedWork W1485115657 @default.
• W1989645441 hasRelatedWork W1970133830 @default.
• W1989645441 hasRelatedWork W1971644035 @default.
• W1989645441 hasRelatedWork W1989645441 @default.
• W1989645441 hasRelatedWork W2745825872 @default.
• W1989645441 hasRelatedWork W3010013908 @default.
• W1989645441 hasRelatedWork W3013154413 @default.
• W1989645441 hasRelatedWork W3015696786 @default.

• next