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- W1989649212 abstract "Quinacrine (mepacrine, Atebrine) is an antiparasitic acridine derivative that is currently used as an intrapleural sclerosing agent. It was determined in plasma by reversed-phase high-performance liquid chromatography of a dichloroethane extract. The mobile phase was methanol-phosphate buffer (65:35) with 0.1 mM decylammonium hydrochloride and 8 mM ethanolammonium hydrochloride. Strong base was added post-column, and the detection of quinacrine was by fluorescence at 270/495 nm. Use of ethacridine lactate as internal standard was feasible but without significant advantage. The coefficient of variation for eight determinations of quinacrine was 4% at 3.4 ng/ml and 5% at 17 ng/ml. The stability of quinacrine in blood, plasma, water and dichloroethane solution was satisfactory for practical work. The usefulness of the analytical procedure for pharmacokinetic studies could be demonstrated." @default.
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- W1989649212 date "1987-01-01" @default.
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- W1989649212 title "Determination of quinacrine (mepacrine) in plasma by high-performance liquid chromatography with fluorimetric detection" @default.
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- W1989649212 doi "https://doi.org/10.1016/0378-4347(87)80189-5" @default.
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