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• W1989653003 abstract "The effects of cyclic AMP on expression of the oncogenes c-myc, c-myb and c-fos in murine P815 mastocytoma cells were examined in relation to growth and differentiation. Induction of differentiation in mastocytoma cells by cyclic AMP was accompanied by a rapid increase in c-fos expression. Cyclic AMP induced stable expression of c-fos mRNA by increasing c-fos transcription 4-5-fold and slightly increasing the stability of c-fos mRNA. However, a high level of c-fos expression was not essential for differentiation of two temperature sensitive-mutant P815 cell lines, as c-fos mRNA did not increase in differentiating temperature-sensitive P815 cells. These results do not support an essential role for c-fos expression in the differentiation of mast cells. Although c-myc expression was lower after growth arrest by cyclic AMP, this decrease did not correlate with growth inhibition by cyclic AMP, since c-myc expression decreased only after cells had started to arrest in G1 phase." @default.
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• W1989653003 creator A5090823484 @default.
• W1989653003 date "1989-01-01" @default.
• W1989653003 modified "2023-09-27" @default.
• W1989653003 title "Cyclic-AMP-induced c-fos expression and its relevance to differentiation of a transformed mast cell line" @default.
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• W1989653003 doi "https://doi.org/10.1016/0167-4781(89)90136-x" @default.
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