Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989661036> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1989661036 endingPage "1171" @default.
- W1989661036 startingPage "1161" @default.
- W1989661036 abstract "Evaluation of the clinical efficacy and safety of a nicotine 2-mg sublingual tablet in smoking cessation.A randomized, double-blind, placebo-controlled study of smokers using the 2-mg tablet for 3-6 months with follow-up to 12 months. Dosing was established according to baseline nicotine dependence, scored on the Fagerström Tolerance Questionnaire (FTQ): FTQ > or = 7, two tablets/hour (maximum 40/day); FTQ < 7, one tablet/hour (maximum 20/day).Smoking cessation programme in a department of oral and maxillofacial surgery.A total of 247 adult smokers, smoking > or = 10 cigarettes/day for > or = 3 years, of whom 123 received active and 124 placebo treatment. The study was powered to detect difference at 6 months.Efficacy and safety were evaluated at 6 weeks and 3, 6 and 12 months. Self-reported abstinence was verified by exhaled CO < 10 p.p.m.Success rates for complete abstinence (no slips after 2 weeks) for active vs. placebo were 50% vs. 29% at 6 weeks, 42% vs. 23% at 3 months, 33% vs. 18% at 6 months and 23% vs. 15% at 12 months (p < 0.001, 0.001, 0.005 and p = 0.14), respectively. Craving during the first 8 days was significantly reduced among highly dependent smokers on active treatment compared to placebo. Baseline mucosal lesions among abstinent subjects were reduced during the treatment period and at the non-treatment follow-up. Adverse events were mild and tolerable, the most common being irritation and soreness in the mouth and throat.The nicotine sublingual tablet increased the smoking cessation rate compared to placebo, reduced craving in highly dependent smokers and was well tolerated." @default.
- W1989661036 created "2016-06-24" @default.
- W1989661036 creator A5026551302 @default.
- W1989661036 creator A5040291238 @default.
- W1989661036 creator A5051193482 @default.
- W1989661036 date "2000-08-01" @default.
- W1989661036 modified "2023-10-02" @default.
- W1989661036 title "A randomized, double-blind, placebo-controlled clinical evaluation of a nicotine sublingual tablet in smoking cessation" @default.
- W1989661036 doi "https://doi.org/10.1046/j.1360-0443.2000.95811613.x" @default.
- W1989661036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11092064" @default.
- W1989661036 hasPublicationYear "2000" @default.
- W1989661036 type Work @default.
- W1989661036 sameAs 1989661036 @default.
- W1989661036 citedByCount "49" @default.
- W1989661036 countsByYear W19896610362012 @default.
- W1989661036 countsByYear W19896610362013 @default.
- W1989661036 countsByYear W19896610362014 @default.
- W1989661036 countsByYear W19896610362015 @default.
- W1989661036 countsByYear W19896610362016 @default.
- W1989661036 countsByYear W19896610362018 @default.
- W1989661036 countsByYear W19896610362019 @default.
- W1989661036 countsByYear W19896610362021 @default.
- W1989661036 countsByYear W19896610362022 @default.
- W1989661036 countsByYear W19896610362023 @default.
- W1989661036 crossrefType "journal-article" @default.
- W1989661036 hasAuthorship W1989661036A5026551302 @default.
- W1989661036 hasAuthorship W1989661036A5040291238 @default.
- W1989661036 hasAuthorship W1989661036A5051193482 @default.
- W1989661036 hasConcept C118552586 @default.
- W1989661036 hasConcept C126322002 @default.
- W1989661036 hasConcept C142724271 @default.
- W1989661036 hasConcept C168563851 @default.
- W1989661036 hasConcept C197934379 @default.
- W1989661036 hasConcept C204787440 @default.
- W1989661036 hasConcept C27081682 @default.
- W1989661036 hasConcept C2777843972 @default.
- W1989661036 hasConcept C2779541405 @default.
- W1989661036 hasConcept C2779547902 @default.
- W1989661036 hasConcept C2780687700 @default.
- W1989661036 hasConcept C42219234 @default.
- W1989661036 hasConcept C48856860 @default.
- W1989661036 hasConcept C71924100 @default.
- W1989661036 hasConceptScore W1989661036C118552586 @default.
- W1989661036 hasConceptScore W1989661036C126322002 @default.
- W1989661036 hasConceptScore W1989661036C142724271 @default.
- W1989661036 hasConceptScore W1989661036C168563851 @default.
- W1989661036 hasConceptScore W1989661036C197934379 @default.
- W1989661036 hasConceptScore W1989661036C204787440 @default.
- W1989661036 hasConceptScore W1989661036C27081682 @default.
- W1989661036 hasConceptScore W1989661036C2777843972 @default.
- W1989661036 hasConceptScore W1989661036C2779541405 @default.
- W1989661036 hasConceptScore W1989661036C2779547902 @default.
- W1989661036 hasConceptScore W1989661036C2780687700 @default.
- W1989661036 hasConceptScore W1989661036C42219234 @default.
- W1989661036 hasConceptScore W1989661036C48856860 @default.
- W1989661036 hasConceptScore W1989661036C71924100 @default.
- W1989661036 hasIssue "8" @default.
- W1989661036 hasLocation W19896610361 @default.
- W1989661036 hasLocation W19896610362 @default.
- W1989661036 hasOpenAccess W1989661036 @default.
- W1989661036 hasPrimaryLocation W19896610361 @default.
- W1989661036 hasRelatedWork W1566313792 @default.
- W1989661036 hasRelatedWork W1981461770 @default.
- W1989661036 hasRelatedWork W2007178261 @default.
- W1989661036 hasRelatedWork W2086792451 @default.
- W1989661036 hasRelatedWork W2151452321 @default.
- W1989661036 hasRelatedWork W2233900235 @default.
- W1989661036 hasRelatedWork W2418331822 @default.
- W1989661036 hasRelatedWork W2717200057 @default.
- W1989661036 hasRelatedWork W2807189903 @default.
- W1989661036 hasRelatedWork W4220960946 @default.
- W1989661036 hasVolume "95" @default.
- W1989661036 isParatext "false" @default.
- W1989661036 isRetracted "false" @default.
- W1989661036 magId "1989661036" @default.
- W1989661036 workType "article" @default.