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- W1989681293 abstract "<h3>To the Editor.—</h3> A recent article in<i>JAMA</i>by Yusuf et al<sup>1</sup>reviewed a large number of trials of interventions for lowering cholesterol levels for the primary and secondary prevention of coronary heart disease. The article states that there was no apparent heterogeneity in reduction of coronary heart disease observed in the drug or dietary intervention trials, in the primary prevention or secondary prevention trials, or on fatal or nonfatal coronary heart disease events. We are unable to comment fully on these assertions as the analysis on which they are based has not been published. However, there is evidence of clinically important differences between trials. For example, in a published work by Yusuf and Furberg,<sup>2</sup>the aggregate risk ratio for coronary heart disease mortality in trials of dietary intervention was 0.99, while aggregation of the trials of lipid-lowering pharmaceutical agents showed a reduction in cardiac mortality for treated" @default.
- W1989681293 created "2016-06-24" @default.
- W1989681293 creator A5060078550 @default.
- W1989681293 date "1989-05-26" @default.
- W1989681293 modified "2023-09-23" @default.
- W1989681293 title "Randomized Clinical Trials in Heart Disease" @default.
- W1989681293 cites W1607175425 @default.
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- W1989681293 doi "https://doi.org/10.1001/jama.1989.03420200042020" @default.
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