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- W1989688609 endingPage "e1002036" @default.
- W1989688609 startingPage "e1002036" @default.
- W1989688609 abstract "Mycobacterium tuberculosis (Mtb) has evolved into a highly successful human pathogen. It deftly subverts the bactericidal mechanisms of alveolar macrophages, ultimately inducing granuloma formation and establishing long-term residence in the host. These hallmarks of Mtb infection are facilitated by the metabolic adaptation of the pathogen to its surrounding environment and the biosynthesis of molecules that mediate its interactions with host immune cells. The sulfate assimilation pathway of Mtb produces a number of sulfur-containing metabolites with important contributions to pathogenesis and survival. This pathway is regulated by diverse environmental cues and regulatory proteins that mediate sulfur transactions in the cell. Here, we discuss the transcriptional and biochemical mechanisms of sulfur metabolism regulation in Mtb and potential small molecule regulators of the sulfate assimilation pathway that are collectively poised to aid this intracellular pathogen in its expert manipulation of the host. From this global analysis, we have identified a subset of sulfur-metabolizing enzymes that are sensitive to multiple regulatory cues and may be strong candidates for therapeutic intervention." @default.
- W1989688609 created "2016-06-24" @default.
- W1989688609 creator A5036036579 @default.
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- W1989688609 date "2011-07-21" @default.
- W1989688609 modified "2023-10-10" @default.
- W1989688609 title "The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis" @default.
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- W1989688609 doi "https://doi.org/10.1371/journal.ppat.1002036" @default.
- W1989688609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3141025" @default.
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