FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989700319> ?p ?o ?g. }

• W1989700319 endingPage "218" @default.
• W1989700319 startingPage "208" @default.
• W1989700319 abstract "Rab proteins are small GTP-binding proteins of the Ras superfamily that function in the regulation of vesicle transport processes. The Rab4 isoform has been implicated in insulin action. For instance, overexpression of a prenylation-deficient form of Rab4 has been shown to inhibit insulin-dependent GLUT4 translocation. Other steps affected by Rab4 in the cascade of events resulting from insulin receptor activation have not been elucidated. In the present studies, we measured effects on insulin-signaling proteins in 3T3-L1 adipocytes transiently expressing cytoplasmic forms of Rab4 and Rab5. Expression of a mutant Rab4 lacking a prenylation site resulted in reduced insulin-dependent phosphorylation of cytoplasmic and internal membrane-associated insulin receptor substrate-1, leading to decreased insulin receptor substrate-1-associated phosphatidylinositol 3′-OH kinase activation and decreased Akt activation. These effects were not observed upon introduction of a similar mutant form of Rab5. These data indicate that Rab4 or a Rab4-associated protein is involved at one or more steps in propagating the insulin signal, in addition to any role it may play in the regulation of GLUT4 vesicle translocation. Our results support models of insulin signaling in which regulation of internal membrane trafficking plays a role in transduction of the insulin signal." @default.
• W1989700319 created "2016-06-24" @default.
• W1989700319 creator A5011721243 @default.
• W1989700319 creator A5060887392 @default.
• W1989700319 creator A5061199927 @default.
• W1989700319 creator A5075457169 @default.
• W1989700319 date "2000-01-01" @default.
• W1989700319 modified "2023-10-16" @default.
• W1989700319 title "Expression of a Prenylation-Deficient Rab4 Interferes with Propagation of Insulin Signaling through Insulin Receptor Substrate-11" @default.
• W1989700319 cites W1500165569 @default.
• W1989700319 cites W1525646795 @default.
• W1989700319 cites W1533598873 @default.
• W1989700319 cites W1547466369 @default.
• W1989700319 cites W1557535868 @default.
• W1989700319 cites W1565184249 @default.
• W1989700319 cites W1570629413 @default.
• W1989700319 cites W1572009433 @default.
• W1989700319 cites W1606305740 @default.
• W1989700319 cites W1643583901 @default.
• W1989700319 cites W167100554 @default.
• W1989700319 cites W1841050729 @default.
• W1989700319 cites W1876891435 @default.
• W1989700319 cites W1963851577 @default.
• W1989700319 cites W1986381441 @default.
• W1989700319 cites W1988370020 @default.
• W1989700319 cites W1989287806 @default.
• W1989700319 cites W1992513963 @default.
• W1989700319 cites W1996281893 @default.
• W1989700319 cites W2002398354 @default.
• W1989700319 cites W2004078164 @default.
• W1989700319 cites W2006358698 @default.
• W1989700319 cites W2010995825 @default.
• W1989700319 cites W2012079492 @default.
• W1989700319 cites W2017487485 @default.
• W1989700319 cites W2026283030 @default.
• W1989700319 cites W2029091584 @default.
• W1989700319 cites W2029722068 @default.
• W1989700319 cites W2032661184 @default.
• W1989700319 cites W2033575261 @default.
• W1989700319 cites W2040792888 @default.
• W1989700319 cites W2040961694 @default.
• W1989700319 cites W2041518788 @default.
• W1989700319 cites W2044868069 @default.
• W1989700319 cites W2047137800 @default.
• W1989700319 cites W2047531477 @default.
• W1989700319 cites W2050604034 @default.
• W1989700319 cites W2056003065 @default.
• W1989700319 cites W2064801081 @default.
• W1989700319 cites W2067930291 @default.
• W1989700319 cites W2090805605 @default.
• W1989700319 cites W2094068658 @default.
• W1989700319 cites W2108544809 @default.
• W1989700319 cites W2110137900 @default.
• W1989700319 cites W2123381133 @default.
• W1989700319 cites W2124615128 @default.
• W1989700319 cites W2125547155 @default.
• W1989700319 cites W2141143622 @default.
• W1989700319 cites W2143692573 @default.
• W1989700319 cites W2145545657 @default.
• W1989700319 cites W2150032835 @default.
• W1989700319 cites W2159615155 @default.
• W1989700319 cites W2167463141 @default.
• W1989700319 cites W2168631501 @default.
• W1989700319 cites W2197535902 @default.
• W1989700319 cites W4239734697 @default.
• W1989700319 cites W89084389 @default.
• W1989700319 doi "https://doi.org/10.1210/endo.141.1.7274" @default.
• W1989700319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10614641" @default.
• W1989700319 hasPublicationYear "2000" @default.
• W1989700319 type Work @default.
• W1989700319 sameAs 1989700319 @default.
• W1989700319 citedByCount "28" @default.
• W1989700319 countsByYear W19897003192012 @default.
• W1989700319 countsByYear W19897003192014 @default.
• W1989700319 countsByYear W19897003192015 @default.
• W1989700319 countsByYear W19897003192016 @default.
• W1989700319 countsByYear W19897003192017 @default.
• W1989700319 countsByYear W19897003192022 @default.
• W1989700319 crossrefType "journal-article" @default.
• W1989700319 hasAuthorship W1989700319A5011721243 @default.
• W1989700319 hasAuthorship W1989700319A5060887392 @default.
• W1989700319 hasAuthorship W1989700319A5061199927 @default.
• W1989700319 hasAuthorship W1989700319A5075457169 @default.
• W1989700319 hasBestOaLocation W19897003191 @default.
• W1989700319 hasConcept C112446052 @default.
• W1989700319 hasConcept C126322002 @default.
• W1989700319 hasConcept C134018914 @default.
• W1989700319 hasConcept C156728348 @default.
• W1989700319 hasConcept C161573976 @default.
• W1989700319 hasConcept C181199279 @default.
• W1989700319 hasConcept C185967709 @default.
• W1989700319 hasConcept C201624660 @default.
• W1989700319 hasConcept C207332259 @default.
• W1989700319 hasConcept C2776188179 @default.
• W1989700319 hasConcept C2777391703 @default.
• W1989700319 hasConcept C2779306644 @default.
• W1989700319 hasConcept C2909831755 @default.
• W1989700319 hasConcept C55493867 @default.

• next