FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989707130> ?p ?o ?g. }

• W1989707130 endingPage "800" @default.
• W1989707130 startingPage "794" @default.
• W1989707130 abstract "Defects in the apoptotic pathway are a general cause for drug resistance. Chemotherapy in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has proven to be an effective strategy to induce apoptosis in vitro in ovarian tumor cells. Systemic TRAIL administration might be a therapeutic option, since no toxicity was observed in nonhuman primates. In the present study, expression of TRAIL and its apoptosis-inducing death receptors (DR4 and DR5) and inhibitory decoy receptor (DcR1) was studied in normal ovaries and in malignant ovarian tumors before and after chemotherapy to investigate the therapeutic potential of TRAIL.DR4, DR5, DcR1, and TRAIL were studied immunohistochemically in 5 normal ovaries, 15 stages I/II, and 26 stages III/IV primary ovarian cancers, including 19 paired tumor samples (pre- and post-chemotherapy).Surface epithelium of normal ovaries expressed TRAIL and its receptors; ovarian stromal cells expressed only DcR1. Of the ovarian cancers, 73% expressed DR4, 51% DR5, 46% DcR1, and 34% TRAIL. Most primary ovarian cancers (88%) expressed at least one death receptor. TRAIL expression was lower in stage III/IV than in stage I/II tumors (P<0.05). In paired samples, DR5 immunostaining was more frequently (P=0.05) and stronger (P<0.01) expressed in residual tumors.Early stage tumors expressed TRAIL more frequently than advanced stage tumors. Most primary and residual ovarian tumors expressed at least one TRAIL death receptor, while in residual tumors following chemotherapy, DR5 was more frequently expressed. Therefore, human recombinant TRAIL administration might be an interesting treatment option." @default.
• W1989707130 created "2016-06-24" @default.
• W1989707130 creator A5003131962 @default.
• W1989707130 creator A5006242728 @default.
• W1989707130 creator A5014747495 @default.
• W1989707130 creator A5016301942 @default.
• W1989707130 creator A5018706155 @default.
• W1989707130 creator A5045329882 @default.
• W1989707130 date "2004-03-01" @default.
• W1989707130 modified "2023-09-30" @default.
• W1989707130 title "Chemotherapy induces death receptor 5 in epithelial ovarian carcinoma" @default.
• W1989707130 cites W1484817497 @default.
• W1989707130 cites W1513799659 @default.
• W1989707130 cites W1534924266 @default.
• W1989707130 cites W1560001018 @default.
• W1989707130 cites W1674551699 @default.
• W1989707130 cites W1975604693 @default.
• W1989707130 cites W1993035278 @default.
• W1989707130 cites W1995182319 @default.
• W1989707130 cites W1995462531 @default.
• W1989707130 cites W2002855877 @default.
• W1989707130 cites W2006405987 @default.
• W1989707130 cites W2011210620 @default.
• W1989707130 cites W2016329566 @default.
• W1989707130 cites W2035207372 @default.
• W1989707130 cites W2041616494 @default.
• W1989707130 cites W2053301688 @default.
• W1989707130 cites W2082368690 @default.
• W1989707130 cites W2084733813 @default.
• W1989707130 cites W2105441981 @default.
• W1989707130 cites W2106284224 @default.
• W1989707130 cites W2119326933 @default.
• W1989707130 cites W2129030898 @default.
• W1989707130 cites W2130407652 @default.
• W1989707130 cites W2130988210 @default.
• W1989707130 cites W2141653146 @default.
• W1989707130 cites W2145356695 @default.
• W1989707130 cites W2154769370 @default.
• W1989707130 cites W2163955558 @default.
• W1989707130 cites W2168084973 @default.
• W1989707130 cites W2326577933 @default.
• W1989707130 cites W2334171427 @default.
• W1989707130 cites W2334639861 @default.
• W1989707130 doi "https://doi.org/10.1016/j.ygyno.2003.11.054" @default.
• W1989707130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14984943" @default.
• W1989707130 hasPublicationYear "2004" @default.
• W1989707130 type Work @default.
• W1989707130 sameAs 1989707130 @default.
• W1989707130 citedByCount "33" @default.
• W1989707130 countsByYear W19897071302012 @default.
• W1989707130 countsByYear W19897071302013 @default.
• W1989707130 countsByYear W19897071302014 @default.
• W1989707130 countsByYear W19897071302016 @default.
• W1989707130 countsByYear W19897071302023 @default.
• W1989707130 crossrefType "journal-article" @default.
• W1989707130 hasAuthorship W1989707130A5003131962 @default.
• W1989707130 hasAuthorship W1989707130A5006242728 @default.
• W1989707130 hasAuthorship W1989707130A5014747495 @default.
• W1989707130 hasAuthorship W1989707130A5016301942 @default.
• W1989707130 hasAuthorship W1989707130A5018706155 @default.
• W1989707130 hasAuthorship W1989707130A5045329882 @default.
• W1989707130 hasConcept C121608353 @default.
• W1989707130 hasConcept C126322002 @default.
• W1989707130 hasConcept C142724271 @default.
• W1989707130 hasConcept C143998085 @default.
• W1989707130 hasConcept C16930146 @default.
• W1989707130 hasConcept C170493617 @default.
• W1989707130 hasConcept C17991360 @default.
• W1989707130 hasConcept C190283241 @default.
• W1989707130 hasConcept C204232928 @default.
• W1989707130 hasConcept C2776694085 @default.
• W1989707130 hasConcept C2778324911 @default.
• W1989707130 hasConcept C2779013556 @default.
• W1989707130 hasConcept C2780084626 @default.
• W1989707130 hasConcept C2780283643 @default.
• W1989707130 hasConcept C2780427987 @default.
• W1989707130 hasConcept C3019054536 @default.
• W1989707130 hasConcept C4224716 @default.
• W1989707130 hasConcept C502942594 @default.
• W1989707130 hasConcept C55493867 @default.
• W1989707130 hasConcept C71924100 @default.
• W1989707130 hasConcept C86803240 @default.
• W1989707130 hasConceptScore W1989707130C121608353 @default.
• W1989707130 hasConceptScore W1989707130C126322002 @default.
• W1989707130 hasConceptScore W1989707130C142724271 @default.
• W1989707130 hasConceptScore W1989707130C143998085 @default.
• W1989707130 hasConceptScore W1989707130C16930146 @default.
• W1989707130 hasConceptScore W1989707130C170493617 @default.
• W1989707130 hasConceptScore W1989707130C17991360 @default.
• W1989707130 hasConceptScore W1989707130C190283241 @default.
• W1989707130 hasConceptScore W1989707130C204232928 @default.
• W1989707130 hasConceptScore W1989707130C2776694085 @default.
• W1989707130 hasConceptScore W1989707130C2778324911 @default.
• W1989707130 hasConceptScore W1989707130C2779013556 @default.
• W1989707130 hasConceptScore W1989707130C2780084626 @default.
• W1989707130 hasConceptScore W1989707130C2780283643 @default.
• W1989707130 hasConceptScore W1989707130C2780427987 @default.
• W1989707130 hasConceptScore W1989707130C3019054536 @default.

• next