FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989711472> ?p ?o ?g. }

• W1989711472 endingPage "479" @default.
• W1989711472 startingPage "472" @default.
• W1989711472 abstract "Recent studies implicate a number of DNA repair proteins in mammalian telomere maintenance. However, because several key repair proteins in mammals are missing from the well-studied budding and fission yeast, their roles at telomeres cannot be modeled in standard fungi. In this report, we explored the dimorphic fungus Ustilago maydis as an alternative model for telomere research. This fungus, which belongs to the phylum Basidiomycota, has a telomere repeat unit that is identical to the mammalian repeat, as well as a constellation of DNA repair proteins that more closely mimic the mammalian collection. We showed that the two core components of homology-directed repair (HDR) in U. maydis, namely Brh2 and Rad51, both promote telomere maintenance in telomerase positive cells, just like in mammals. In addition, we found that Brh2 is localized to telomeres in vivo, suggesting that it acts directly at chromosome ends. We surveyed a series of mutants with DNA repair defects, and found many of them to have short telomeres. Our results indicate that factors involved in DNA repair are probably also needed for optimal telomere maintenance in U. maydis, and that this fungus is a useful alternative model system for telomere research." @default.
• W1989711472 created "2016-06-24" @default.
• W1989711472 creator A5001142502 @default.
• W1989711472 creator A5036522614 @default.
• W1989711472 creator A5053361953 @default.
• W1989711472 creator A5065552028 @default.
• W1989711472 date "2013-07-01" @default.
• W1989711472 modified "2023-10-01" @default.
• W1989711472 title "Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres" @default.
• W1989711472 cites W1590341185 @default.
• W1989711472 cites W1965324768 @default.
• W1989711472 cites W1965343035 @default.
• W1989711472 cites W1965730187 @default.
• W1989711472 cites W1970445060 @default.
• W1989711472 cites W1971240706 @default.
• W1989711472 cites W1973544851 @default.
• W1989711472 cites W1978143588 @default.
• W1989711472 cites W1989343323 @default.
• W1989711472 cites W1991754576 @default.
• W1989711472 cites W1992708636 @default.
• W1989711472 cites W1999247982 @default.
• W1989711472 cites W2007067931 @default.
• W1989711472 cites W2007497503 @default.
• W1989711472 cites W2011882274 @default.
• W1989711472 cites W2016646630 @default.
• W1989711472 cites W2019862267 @default.
• W1989711472 cites W2022013301 @default.
• W1989711472 cites W2037654635 @default.
• W1989711472 cites W2045017146 @default.
• W1989711472 cites W2047913628 @default.
• W1989711472 cites W2052490288 @default.
• W1989711472 cites W2059956126 @default.
• W1989711472 cites W2060896826 @default.
• W1989711472 cites W2060955969 @default.
• W1989711472 cites W2061221974 @default.
• W1989711472 cites W2064032731 @default.
• W1989711472 cites W2068394064 @default.
• W1989711472 cites W2069480469 @default.
• W1989711472 cites W2074429117 @default.
• W1989711472 cites W2092512523 @default.
• W1989711472 cites W2100929591 @default.
• W1989711472 cites W2104191744 @default.
• W1989711472 cites W2105096274 @default.
• W1989711472 cites W2109879947 @default.
• W1989711472 cites W2111250240 @default.
• W1989711472 cites W2114773424 @default.
• W1989711472 cites W2119463579 @default.
• W1989711472 cites W2124242199 @default.
• W1989711472 cites W2125194621 @default.
• W1989711472 cites W2126726250 @default.
• W1989711472 cites W2131666315 @default.
• W1989711472 cites W2140895326 @default.
• W1989711472 cites W2141288561 @default.
• W1989711472 cites W2142741915 @default.
• W1989711472 cites W2149390987 @default.
• W1989711472 cites W2152562488 @default.
• W1989711472 cites W2152768207 @default.
• W1989711472 cites W2156885977 @default.
• W1989711472 cites W2168519261 @default.
• W1989711472 cites W2170250771 @default.
• W1989711472 cites W2170773702 @default.
• W1989711472 cites W4236235546 @default.
• W1989711472 doi "https://doi.org/10.1016/j.dnarep.2013.04.027" @default.
• W1989711472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3684436" @default.
• W1989711472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23726221" @default.
• W1989711472 hasPublicationYear "2013" @default.
• W1989711472 type Work @default.
• W1989711472 sameAs 1989711472 @default.
• W1989711472 citedByCount "21" @default.
• W1989711472 countsByYear W19897114722014 @default.
• W1989711472 countsByYear W19897114722015 @default.
• W1989711472 countsByYear W19897114722016 @default.
• W1989711472 countsByYear W19897114722017 @default.
• W1989711472 countsByYear W19897114722018 @default.
• W1989711472 countsByYear W19897114722019 @default.
• W1989711472 countsByYear W19897114722020 @default.
• W1989711472 countsByYear W19897114722021 @default.
• W1989711472 countsByYear W19897114722022 @default.
• W1989711472 countsByYear W19897114722023 @default.
• W1989711472 crossrefType "journal-article" @default.
• W1989711472 hasAuthorship W1989711472A5001142502 @default.
• W1989711472 hasAuthorship W1989711472A5036522614 @default.
• W1989711472 hasAuthorship W1989711472A5053361953 @default.
• W1989711472 hasAuthorship W1989711472A5065552028 @default.
• W1989711472 hasBestOaLocation W19897114722 @default.
• W1989711472 hasConcept C102744134 @default.
• W1989711472 hasConcept C104317684 @default.
• W1989711472 hasConcept C134935766 @default.
• W1989711472 hasConcept C177336024 @default.
• W1989711472 hasConcept C202265312 @default.
• W1989711472 hasConcept C2779012473 @default.
• W1989711472 hasConcept C2781222273 @default.
• W1989711472 hasConcept C54355233 @default.
• W1989711472 hasConcept C552990157 @default.
• W1989711472 hasConcept C86339819 @default.
• W1989711472 hasConcept C86803240 @default.
• W1989711472 hasConcept C94581717 @default.
• W1989711472 hasConcept C94966510 @default.

• next