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• W1989735653 startingPage "633" @default.
• W1989735653 abstract "Although the potentiating effects of ethanol and cocaine have been well documented, little has been reported regarding the effects of ethanol or cocaine history on this interaction. In the present study, female Long-Evans rats received five exposures to ethanol (3.5 g/kg ip) or vehicle prior to taste aversion conditioning in which a novel saccharin solution was paired with either ethanol (0.56 g/kg ip), cocaine (25 mg/kg sc) or the combination (or the drugs' vehicle) for a total of five conditioning trials. Nonpreexposed subjects conditioned with the ethanol/cocaine combination displayed aversions, drinking levels significantly less than nonpreexposed subjects conditioned with either drug alone. Further, the aversions produced by the combination were greater than the sum of the aversions produced by ethanol and cocaine, alone. Ethanol-preexposed animals conditioned with the combination displayed an attenuated aversion, drinking significantly greater amounts of saccharin than nonpreexposed conditioned subjects and not differing from controls. Although the basis for the attenuation by ethanol of the aversions induced by the drug combination is not known, the present findings may have implications for the use and abuse of the combination in that alcohol history may reduce the subsequent toxicity of the combination that in turn may affect its acceptability." @default.
• W1989735653 created "2016-06-24" @default.
• W1989735653 creator A5052421144 @default.
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• W1989735653 date "2002-06-01" @default.
• W1989735653 modified "2023-09-26" @default.
• W1989735653 title "Ethanol preexposure attenuates the interaction of ethanol and cocaine in taste aversion learning" @default.
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• W1989735653 doi "https://doi.org/10.1016/s0091-3057(02)00726-8" @default.
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