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- W1989751531 abstract "A novel modular synthetic approach toward constrained peptidomimetics is reported. The approach involves a highly efficient three-step sequence including two multicomponent reactions, thus allowing unprecedented diversification of both the peptide moieties and the turn-inducing scaffold. The turn-inducing properties of the dihydropyridone scaffold were evaluated by molecular modeling, X-ray crystallography, and NMR studies of a resulting peptidomimetic. Although modeling studies point toward a type IV β-turn-like structure, the X-ray crystal structure and NMR studies indicate an open turn structure." @default.
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- W1989751531 date "2008-12-04" @default.
- W1989751531 modified "2023-09-23" @default.
- W1989751531 title "Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent Reactions" @default.
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- W1989751531 doi "https://doi.org/10.1021/jo802052j" @default.
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