FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989752793> ?p ?o ?g. }

• W1989752793 abstract "The reactions of the methionine/homocysteine pathway are mediated by several enzymes, including phosphatidylethanolamine N-methyltransferase, cystathionine β-synthase, and betaine-homocysteine methyltransferase. Homocysteine homeostasis is regulated by these enzymes. We hypothesized here that the protein and folic acid content in the maternal diet affects methionine/homocysteine metabolism in the progeny. To test this hypothesis, pregnant rats were fed a diet with normal protein and normal folic acid levels (a modified casein-based AIN-93G diet), a protein-restricted and normal folic acid diet, a protein-restricted and folic acid-supplemented diet, or a normal protein and folic acid-supplemented diet. The progeny were fed either the modified AIN-93G diet or a high-fat lard-based diet. Progeny were analyzed for expression of the phosphatidylethanolamine N-methyltransferase, cystathionine β-synthase, and betaine-homocysteine methyltransferase genes in the liver and for serum homocysteine concentration. Interactions between prenatal and postnatal nutrition were also determined. The progeny of the dams fed the diets supplemented with folic acid showed decreased expression of all 3 genes (P < .001). An interaction effect between the protein and folic acid content in the maternal diet contributed to this down-regulation (P < .001), and the postweaning diet modified these effects. Serum homocysteine concentrations were approximately 15% higher in the male rats (P < .01), but neither prenatal nutrition nor the postweaning diet affected it significantly. We conclude that maternal diet during gestation has an important effect on the transcription level of these 3 genes, but changes in gene expression were not associated with significant changes in progeny homocysteine concentrations." @default.
• W1989752793 created "2016-06-24" @default.
• W1989752793 creator A5025743886 @default.
• W1989752793 creator A5039583248 @default.
• W1989752793 date "2011-07-01" @default.
• W1989752793 modified "2023-10-03" @default.
• W1989752793 title "Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein and folic acid intake during pregnancy and fat intake after weaning" @default.
• W1989752793 cites W104618638 @default.
• W1989752793 cites W1577577364 @default.
• W1989752793 cites W1864672679 @default.
• W1989752793 cites W1932533342 @default.
• W1989752793 cites W1951172546 @default.
• W1989752793 cites W1973462388 @default.
• W1989752793 cites W1986835810 @default.
• W1989752793 cites W1987479360 @default.
• W1989752793 cites W1993932990 @default.
• W1989752793 cites W1998354299 @default.
• W1989752793 cites W2004345371 @default.
• W1989752793 cites W2023086764 @default.
• W1989752793 cites W2041778509 @default.
• W1989752793 cites W2044242318 @default.
• W1989752793 cites W2054847530 @default.
• W1989752793 cites W2063777054 @default.
• W1989752793 cites W2067423374 @default.
• W1989752793 cites W2069037942 @default.
• W1989752793 cites W2075507230 @default.
• W1989752793 cites W2080049485 @default.
• W1989752793 cites W2089961269 @default.
• W1989752793 cites W2096534598 @default.
• W1989752793 cites W2099680351 @default.
• W1989752793 cites W2100313057 @default.
• W1989752793 cites W2100489386 @default.
• W1989752793 cites W2105686571 @default.
• W1989752793 cites W2108283346 @default.
• W1989752793 cites W2110778540 @default.
• W1989752793 cites W2113507341 @default.
• W1989752793 cites W2119909792 @default.
• W1989752793 cites W2120015909 @default.
• W1989752793 cites W2126340847 @default.
• W1989752793 cites W2138439179 @default.
• W1989752793 cites W2140093065 @default.
• W1989752793 cites W2141059309 @default.
• W1989752793 cites W2148372309 @default.
• W1989752793 cites W2159409293 @default.
• W1989752793 cites W2163356096 @default.
• W1989752793 cites W2164020759 @default.
• W1989752793 cites W2164754045 @default.
• W1989752793 cites W2166148002 @default.
• W1989752793 cites W2166169146 @default.
• W1989752793 cites W2166598490 @default.
• W1989752793 cites W2167106684 @default.
• W1989752793 cites W3184321 @default.
• W1989752793 cites W196165009 @default.
• W1989752793 doi "https://doi.org/10.1016/j.nutres.2011.07.001" @default.
• W1989752793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21840474" @default.
• W1989752793 hasPublicationYear "2011" @default.
• W1989752793 type Work @default.
• W1989752793 sameAs 1989752793 @default.
• W1989752793 citedByCount "7" @default.
• W1989752793 countsByYear W19897527932012 @default.
• W1989752793 countsByYear W19897527932014 @default.
• W1989752793 countsByYear W19897527932016 @default.
• W1989752793 countsByYear W19897527932017 @default.
• W1989752793 countsByYear W19897527932018 @default.
• W1989752793 countsByYear W19897527932019 @default.
• W1989752793 crossrefType "journal-article" @default.
• W1989752793 hasAuthorship W1989752793A5025743886 @default.
• W1989752793 hasAuthorship W1989752793A5039583248 @default.
• W1989752793 hasConcept C104317684 @default.
• W1989752793 hasConcept C126322002 @default.
• W1989752793 hasConcept C134018914 @default.
• W1989752793 hasConcept C16525657 @default.
• W1989752793 hasConcept C2777090595 @default.
• W1989752793 hasConcept C2777248517 @default.
• W1989752793 hasConcept C2780912031 @default.
• W1989752793 hasConcept C33288867 @default.
• W1989752793 hasConcept C515207424 @default.
• W1989752793 hasConcept C55493867 @default.
• W1989752793 hasConcept C71924100 @default.
• W1989752793 hasConcept C80315684 @default.
• W1989752793 hasConcept C86803240 @default.
• W1989752793 hasConcept C91965660 @default.
• W1989752793 hasConceptScore W1989752793C104317684 @default.
• W1989752793 hasConceptScore W1989752793C126322002 @default.
• W1989752793 hasConceptScore W1989752793C134018914 @default.
• W1989752793 hasConceptScore W1989752793C16525657 @default.
• W1989752793 hasConceptScore W1989752793C2777090595 @default.
• W1989752793 hasConceptScore W1989752793C2777248517 @default.
• W1989752793 hasConceptScore W1989752793C2780912031 @default.
• W1989752793 hasConceptScore W1989752793C33288867 @default.
• W1989752793 hasConceptScore W1989752793C515207424 @default.
• W1989752793 hasConceptScore W1989752793C55493867 @default.
• W1989752793 hasConceptScore W1989752793C71924100 @default.
• W1989752793 hasConceptScore W1989752793C80315684 @default.
• W1989752793 hasConceptScore W1989752793C86803240 @default.
• W1989752793 hasConceptScore W1989752793C91965660 @default.
• W1989752793 hasLocation W19897527931 @default.
• W1989752793 hasLocation W19897527932 @default.
• W1989752793 hasOpenAccess W1989752793 @default.
• W1989752793 hasPrimaryLocation W19897527931 @default.

• next