Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989753269> ?p ?o ?g. }
- W1989753269 endingPage "278" @default.
- W1989753269 startingPage "274" @default.
- W1989753269 abstract "Keratinocytes produce multiple cytokines in response to a variety of stimuli. The release of interleukin 1 (IL-1) from keratinocytes may be significant in initiation of cutaneous inflammation, and the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF) is thought to be important in the regulation of antigen-presenting function by epidermal Langerhans cells. Because cyclosporin inhibits interleukin 2 release from T cells, it has been suggested that cyclosporin may function as an anti-inflammatory agent within the epidermis through inhibition of keratinocyte cytokine release. This investigation examined the direct effect of cyclosporin on the production of GM-CSF by murine keratinocytes and the keratinocyte cell line PAM 212. GM-CSF bioactivity increased in cell supernatants from keratinocytes exposed in vitro to 1 microgram/ml cyclosporin for up to 24 h. GM-CSF and IL-1 mRNA levels in keratinocytes cultured under similar conditions or in the presence of lipopolysaccharide also increased. The lack of inhibition of GM-CSF expression following cyclosporin treatment is consistent with recent observations in T cells and is opposite to the effect of cyclosporin on interleukin 2." @default.
- W1989753269 created "2016-06-24" @default.
- W1989753269 creator A5011524597 @default.
- W1989753269 creator A5035174263 @default.
- W1989753269 creator A5039631810 @default.
- W1989753269 creator A5042304008 @default.
- W1989753269 creator A5046274963 @default.
- W1989753269 date "1992-03-01" @default.
- W1989753269 modified "2023-10-15" @default.
- W1989753269 title "Cyclosporin Increases Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Activity and Gene Expression in Murine Keratinocytes" @default.
- W1989753269 cites W1486757560 @default.
- W1989753269 cites W1503075228 @default.
- W1989753269 cites W1541007861 @default.
- W1989753269 cites W1640509666 @default.
- W1989753269 cites W1650036545 @default.
- W1989753269 cites W1699203261 @default.
- W1989753269 cites W1965525538 @default.
- W1989753269 cites W1971955881 @default.
- W1989753269 cites W1973359682 @default.
- W1989753269 cites W1978344504 @default.
- W1989753269 cites W1982920370 @default.
- W1989753269 cites W1993169352 @default.
- W1989753269 cites W1997411530 @default.
- W1989753269 cites W2010350911 @default.
- W1989753269 cites W2048043023 @default.
- W1989753269 cites W2048220863 @default.
- W1989753269 cites W2053131178 @default.
- W1989753269 cites W2053719727 @default.
- W1989753269 cites W2054012934 @default.
- W1989753269 cites W2060695790 @default.
- W1989753269 cites W2071972670 @default.
- W1989753269 cites W2073966923 @default.
- W1989753269 cites W2088685548 @default.
- W1989753269 cites W2090146012 @default.
- W1989753269 cites W2104062445 @default.
- W1989753269 cites W2158474160 @default.
- W1989753269 cites W4246271143 @default.
- W1989753269 cites W4255940022 @default.
- W1989753269 cites W4294216491 @default.
- W1989753269 doi "https://doi.org/10.1111/1523-1747.ep12497858" @default.
- W1989753269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1545136" @default.
- W1989753269 hasPublicationYear "1992" @default.
- W1989753269 type Work @default.
- W1989753269 sameAs 1989753269 @default.
- W1989753269 citedByCount "11" @default.
- W1989753269 crossrefType "journal-article" @default.
- W1989753269 hasAuthorship W1989753269A5011524597 @default.
- W1989753269 hasAuthorship W1989753269A5035174263 @default.
- W1989753269 hasAuthorship W1989753269A5039631810 @default.
- W1989753269 hasAuthorship W1989753269A5042304008 @default.
- W1989753269 hasAuthorship W1989753269A5046274963 @default.
- W1989753269 hasConcept C105702510 @default.
- W1989753269 hasConcept C126322002 @default.
- W1989753269 hasConcept C131665280 @default.
- W1989753269 hasConcept C134018914 @default.
- W1989753269 hasConcept C202751555 @default.
- W1989753269 hasConcept C203014093 @default.
- W1989753269 hasConcept C2776090121 @default.
- W1989753269 hasConcept C2776458125 @default.
- W1989753269 hasConcept C2777074287 @default.
- W1989753269 hasConcept C2777478134 @default.
- W1989753269 hasConcept C2777983669 @default.
- W1989753269 hasConcept C2778690821 @default.
- W1989753269 hasConcept C2778754761 @default.
- W1989753269 hasConcept C2779244956 @default.
- W1989753269 hasConcept C54355233 @default.
- W1989753269 hasConcept C55493867 @default.
- W1989753269 hasConcept C67662055 @default.
- W1989753269 hasConcept C71924100 @default.
- W1989753269 hasConcept C74172505 @default.
- W1989753269 hasConcept C81885089 @default.
- W1989753269 hasConcept C86803240 @default.
- W1989753269 hasConcept C8891405 @default.
- W1989753269 hasConceptScore W1989753269C105702510 @default.
- W1989753269 hasConceptScore W1989753269C126322002 @default.
- W1989753269 hasConceptScore W1989753269C131665280 @default.
- W1989753269 hasConceptScore W1989753269C134018914 @default.
- W1989753269 hasConceptScore W1989753269C202751555 @default.
- W1989753269 hasConceptScore W1989753269C203014093 @default.
- W1989753269 hasConceptScore W1989753269C2776090121 @default.
- W1989753269 hasConceptScore W1989753269C2776458125 @default.
- W1989753269 hasConceptScore W1989753269C2777074287 @default.
- W1989753269 hasConceptScore W1989753269C2777478134 @default.
- W1989753269 hasConceptScore W1989753269C2777983669 @default.
- W1989753269 hasConceptScore W1989753269C2778690821 @default.
- W1989753269 hasConceptScore W1989753269C2778754761 @default.
- W1989753269 hasConceptScore W1989753269C2779244956 @default.
- W1989753269 hasConceptScore W1989753269C54355233 @default.
- W1989753269 hasConceptScore W1989753269C55493867 @default.
- W1989753269 hasConceptScore W1989753269C67662055 @default.
- W1989753269 hasConceptScore W1989753269C71924100 @default.
- W1989753269 hasConceptScore W1989753269C74172505 @default.
- W1989753269 hasConceptScore W1989753269C81885089 @default.
- W1989753269 hasConceptScore W1989753269C86803240 @default.
- W1989753269 hasConceptScore W1989753269C8891405 @default.
- W1989753269 hasIssue "3" @default.
- W1989753269 hasLocation W19897532691 @default.
- W1989753269 hasLocation W19897532692 @default.