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- W1989767122 abstract "The association of microsatellite instability (MSI) and colorectal cancer has been studied. However, it is unknown whether early gastric cancer (EGC) patients with MSI are at higher risk for colon adenomatous polyp From May 2005 to May 2010, 413 patients diagnosed EGC underwent endoscopic submucosal dissection (ESD). MSI was examined by fluorescence based polymerase chain reaction using five NCI panel markers (BAT25, BAT26, D2S123, D5S346, D17S250) in 257 patients of EGC. The 118 patients who received both microsatellite stability test and colonoscopy were investigated. Correlation between presence of MSI and colonic adenomatous polyp was evaluated. Mean age was 61(33∼84). Of 118 patients, Male were 89 (75.4%) and female were 29 (24.6%). Mucosal cancer was 97 (82.2%) and differentiated cancer was 95 (80.5%). Tumor location was as follows; upper 10 (8.5%), mid 44 (37.3%), lower 64 (54.2%), respectively. Mucin phenotypes were as follows; gastric 32 (27.1%), intestinal 37 (31.4%), mixed 49 (41.5%). Microsatellite stability (MSS) showed 85 patients and MSS with colon adenomatous polyp showed 25 patients. MSI showed 33 patients and MSI with colon adenomatous polyp showed 23 patients. Finally, alteration of MSI showed significant relationship for the presence of colon adenomatous polyp (p<0.001). The risk of colon adnomatous polyp increases significantly in early gastric cancer patients with MSI. A routine colonoscopy may be necessary for patients with early gastric cancer to detect colon adenomatous polyp." @default.
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- W1989767122 date "2011-04-01" @default.
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- W1989767122 title "Sa1662 Clinical Association Between Microsatellite Instability in Early Gastric Cancer and Colon Adenomatous Polyp" @default.
- W1989767122 doi "https://doi.org/10.1016/j.gie.2011.03.397" @default.
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