Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989783456> ?p ?o ?g. }
- W1989783456 endingPage "131" @default.
- W1989783456 startingPage "126" @default.
- W1989783456 abstract "A theoretical inverse relationship has long been postulated for osteogenic and adipogenic differentiation (bone versus adipose tissue differentiation). This inverse relationship in theory at least partially underlies the clinical entity of osteoporosis, in which marrow mesenchymal stem cells (MSCs) have a predilection for adipose differentiation that increases with age. In the present study, we assayed the potential anti-adipogenic effects of Nell-1 protein (an osteoinductive molecule). Using 3T3-L1 (a human preadipocyte cell line) cells and human adipose-derived stromal cells (ASCs), we observed that adenoviral delivered (Ad)-Nell-1 or recombinant NELL-1 protein significantly reduced adipose differentiation across all markers examined (Oil red O staining, adipogenic gene expression [Pparg, Lpl, Ap2]). In a prospective fashion, Hedgehog signaling was assayed as potentially downstream of Nell-1 signaling in regulating osteogenic over adipogenic differentiation. In comparison to Ad-LacZ control, Ad-Nell-1 increased expression of hedgehog signaling markers (Ihh, Gli1, Ptc1). These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog dependent mechanism." @default.
- W1989783456 created "2016-06-24" @default.
- W1989783456 creator A5020641338 @default.
- W1989783456 creator A5035789468 @default.
- W1989783456 creator A5040243865 @default.
- W1989783456 creator A5059444790 @default.
- W1989783456 creator A5064932750 @default.
- W1989783456 creator A5070790575 @default.
- W1989783456 creator A5079392008 @default.
- W1989783456 date "2011-07-01" @default.
- W1989783456 modified "2023-10-06" @default.
- W1989783456 title "A new function of Nell-1 protein in repressing adipogenic differentiation" @default.
- W1989783456 cites W1944656442 @default.
- W1989783456 cites W1976620205 @default.
- W1989783456 cites W1981525131 @default.
- W1989783456 cites W1984640923 @default.
- W1989783456 cites W1986648749 @default.
- W1989783456 cites W1994923386 @default.
- W1989783456 cites W1995499476 @default.
- W1989783456 cites W2012334457 @default.
- W1989783456 cites W2026303920 @default.
- W1989783456 cites W2031066958 @default.
- W1989783456 cites W2031580405 @default.
- W1989783456 cites W2039261109 @default.
- W1989783456 cites W2043129312 @default.
- W1989783456 cites W2044687174 @default.
- W1989783456 cites W2054293859 @default.
- W1989783456 cites W2058902172 @default.
- W1989783456 cites W2061626791 @default.
- W1989783456 cites W2075494055 @default.
- W1989783456 cites W2081746983 @default.
- W1989783456 cites W2083744994 @default.
- W1989783456 cites W2086543433 @default.
- W1989783456 cites W2093985074 @default.
- W1989783456 cites W2094254575 @default.
- W1989783456 cites W2094907909 @default.
- W1989783456 cites W2100878513 @default.
- W1989783456 cites W2101431584 @default.
- W1989783456 cites W2132620372 @default.
- W1989783456 cites W2143658021 @default.
- W1989783456 cites W2155882794 @default.
- W1989783456 cites W2160870063 @default.
- W1989783456 cites W2167927701 @default.
- W1989783456 cites W2330856931 @default.
- W1989783456 cites W4230953913 @default.
- W1989783456 doi "https://doi.org/10.1016/j.bbrc.2011.06.111" @default.
- W1989783456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166249" @default.
- W1989783456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21723263" @default.
- W1989783456 hasPublicationYear "2011" @default.
- W1989783456 type Work @default.
- W1989783456 sameAs 1989783456 @default.
- W1989783456 citedByCount "55" @default.
- W1989783456 countsByYear W19897834562012 @default.
- W1989783456 countsByYear W19897834562013 @default.
- W1989783456 countsByYear W19897834562014 @default.
- W1989783456 countsByYear W19897834562015 @default.
- W1989783456 countsByYear W19897834562016 @default.
- W1989783456 countsByYear W19897834562017 @default.
- W1989783456 countsByYear W19897834562018 @default.
- W1989783456 countsByYear W19897834562019 @default.
- W1989783456 countsByYear W19897834562020 @default.
- W1989783456 countsByYear W19897834562021 @default.
- W1989783456 countsByYear W19897834562022 @default.
- W1989783456 countsByYear W19897834562023 @default.
- W1989783456 crossrefType "journal-article" @default.
- W1989783456 hasAuthorship W1989783456A5020641338 @default.
- W1989783456 hasAuthorship W1989783456A5035789468 @default.
- W1989783456 hasAuthorship W1989783456A5040243865 @default.
- W1989783456 hasAuthorship W1989783456A5059444790 @default.
- W1989783456 hasAuthorship W1989783456A5064932750 @default.
- W1989783456 hasAuthorship W1989783456A5070790575 @default.
- W1989783456 hasAuthorship W1989783456A5079392008 @default.
- W1989783456 hasBestOaLocation W19897834562 @default.
- W1989783456 hasConcept C104317684 @default.
- W1989783456 hasConcept C122927707 @default.
- W1989783456 hasConcept C126322002 @default.
- W1989783456 hasConcept C134018914 @default.
- W1989783456 hasConcept C142536801 @default.
- W1989783456 hasConcept C148738053 @default.
- W1989783456 hasConcept C16930146 @default.
- W1989783456 hasConcept C171089720 @default.
- W1989783456 hasConcept C198826908 @default.
- W1989783456 hasConcept C2778539099 @default.
- W1989783456 hasConcept C2780806160 @default.
- W1989783456 hasConcept C502942594 @default.
- W1989783456 hasConcept C55493867 @default.
- W1989783456 hasConcept C62478195 @default.
- W1989783456 hasConcept C71924100 @default.
- W1989783456 hasConcept C86803240 @default.
- W1989783456 hasConcept C88498014 @default.
- W1989783456 hasConcept C95444343 @default.
- W1989783456 hasConceptScore W1989783456C104317684 @default.
- W1989783456 hasConceptScore W1989783456C122927707 @default.
- W1989783456 hasConceptScore W1989783456C126322002 @default.
- W1989783456 hasConceptScore W1989783456C134018914 @default.
- W1989783456 hasConceptScore W1989783456C142536801 @default.
- W1989783456 hasConceptScore W1989783456C148738053 @default.
- W1989783456 hasConceptScore W1989783456C16930146 @default.