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- W1989794930 abstract "The effects of pentylenetetrazol (PTZ,Metrazol) on step-through inhibitory avoidance behavior, brain seizure activity, and Z3H]lysine incorporation into brain proteins were examined in Swiss/ICR and C57B1/6J mice. Immediate post-training administration of PTZ (60 mg/kg) resulted in significant retention deficits in both strains of mice when tested 24 hr later. In Swiss/ICR mice, subconvulsive doses of PTZ (50 mg/kg) were sufficient to produce amnesia, and there was no correlation between the presence or absence of convulsions and the induction of amnesia. Electrographic recordings from the cerebral cortex and hippocampus indicated that behavorial convulsions always accompanied sustained high-voltage spiking activity in the hippocampus and cortex. Both convulsive and nonconvulsive doses of PTZ inhibited the incorporation of Z3H]lysine into brain proteins during the first 10 min after training and PTZ administration. There was no correlation between the presence or absence of convulsions and the degree of inhibition of Z3H]lysine incorporation in the brains of Swiss/ICR mice receiving 50 mg/kg of PTZ. PTZ also inhibited Z3H]lysine incorporation into liver proteins. In C57B1/6J mice administered a convulsive dose of PTZ, the inhibition of Z3H]lysine incorporation showed the following regional distribution: cortex > diencephalon + striatum > hippocampus ⋍ brainstem. Thus, PTZ both produced amnesia and inhibited the incorporation of Z3H]lysine into brain proteins in the absence of gross electrographic abnormalities, but neither of these effects was related to the presence or absence of convulsions." @default.
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- W1989794930 date "2007-10-01" @default.
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- W1989794930 title "Validation of the effects of progesterone and MK-801 on acute phase changes induced by partial global cerebral ischemia in mice" @default.
- W1989794930 doi "https://doi.org/10.1016/j.toxlet.2007.05.187" @default.
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