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• W1989797465 abstract "Heterogeneous nuclear ribonucleoproteins (hnRNPs) are abundant RNA-binding proteins that are implicated in splicing regulation. Here we investigate the role of a Drosophila hnRNP in splicing regulation in living animals. We find that overexpression of the Drosophila hnRNP HRB98DE leads to skipping of all internal exons in the Drosophila dopa decarboxylase (Ddc) pre-mRNA in vivo. These results indicate that HRB98DE has a splicing activity that promotes use of terminal splice sites. The effect of excess HRB98DE on Ddc splicing is transient, even though high levels of HRB98DE persist for at least 24 hr. This suggests that Drosophila larvae can induce a compensating mechanism to counteract the effects of excess HRB98DE." @default.
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• W1989797465 date "1995-03-14" @default.
• W1989797465 modified "2023-09-24" @default.
• W1989797465 title "Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleoprotein in vivo." @default.
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• W1989797465 doi "https://doi.org/10.1073/pnas.92.6.1822" @default.
• W1989797465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/42374" @default.
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