FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989798009> ?p ?o ?g. }

• W1989798009 abstract "The effects of kainate on membrane current and membrane conductance were investigated in presumed hilar glial precursor cells of juvenile rats. The perforated-patch configuration was used also to reveal possible second-messenger effects. Kainate evoked an inward current that was accompanied by a biphasic change in membrane conductance in 69% of the cells. An initial conductance increase with a time course similar to that of the inward current was followed by a second delayed conductance increase. This second conductance was absent in whole-cell-clamp recordings, suggesting that it was mediated by a second messenger effect. Analysis of the reversal potentials of the membrane current during both phases of the kainate-induced conductance change revealed that the first conductance increase reflected the activation of AMPA receptors. Several lines of evidence suggest that the delayed second conductance increase was due to the indirect activation of Ca2+-dependent K+ channels via Ca2+-influx through AMPA receptors. (1) the delayed second conductance increase was blocked by Ba2+ and the reversal of its underlying current was significantly shifted towards EK+, suggesting that it is due to the activation of K+ channels. (2) The delayed second conductance increase disappeared in a Ca2+-free saline buffered with BAPTA, indicating that it depended on Ca2+-influx. (3) Co2+, Cd2+ and nimodipine failed to block the delayed second conductance increase excluding a major contribution of voltage-dependent Ca2+ channels. (4) The involvement of metabotropic glutamate receptors also appeared unlikely, because the kainate-induced delayed second conductance increase could not be blocked by a depletion of the intracellular Ca2+ stores with the Ca2+-ATPase inhibitor thapsigargin, and t-ACPD exerted no effect on membrane current and conductance. We conclude that kainate activates directly AMPA receptors in presumed hilar glial precursor cells. This results in a Ca2+ influx that could lead indirectly to the activation of Ca2+-dependent K+ channels." @default.
• W1989798009 created "2016-06-24" @default.
• W1989798009 creator A5019632330 @default.
• W1989798009 creator A5070349543 @default.
• W1989798009 creator A5089108079 @default.
• W1989798009 date "1998-05-01" @default.
• W1989798009 modified "2023-09-27" @default.
• W1989798009 title "Effect of kainate on the membrane conductance of hilar glial precursor cells recorded in the perforated-patch configuration" @default.
• W1989798009 cites W1445544398 @default.
• W1989798009 cites W1572456805 @default.
• W1989798009 cites W1964845842 @default.
• W1989798009 cites W1973476654 @default.
• W1989798009 cites W1980979304 @default.
• W1989798009 cites W1987970152 @default.
• W1989798009 cites W1991143203 @default.
• W1989798009 cites W1992413200 @default.
• W1989798009 cites W1996892917 @default.
• W1989798009 cites W2001320373 @default.
• W1989798009 cites W2007884285 @default.
• W1989798009 cites W2009667219 @default.
• W1989798009 cites W2012398018 @default.
• W1989798009 cites W2019861866 @default.
• W1989798009 cites W2022889768 @default.
• W1989798009 cites W2037495414 @default.
• W1989798009 cites W2037993046 @default.
• W1989798009 cites W2043166209 @default.
• W1989798009 cites W2047225757 @default.
• W1989798009 cites W2051953163 @default.
• W1989798009 cites W2054665431 @default.
• W1989798009 cites W2057648028 @default.
• W1989798009 cites W2061210518 @default.
• W1989798009 cites W2062963816 @default.
• W1989798009 cites W2063535351 @default.
• W1989798009 cites W2069193323 @default.
• W1989798009 cites W2070169336 @default.
• W1989798009 cites W2071956912 @default.
• W1989798009 cites W2078395247 @default.
• W1989798009 cites W2082331948 @default.
• W1989798009 cites W2085726430 @default.
• W1989798009 cites W2087667366 @default.
• W1989798009 cites W2090547765 @default.
• W1989798009 cites W2095549425 @default.
• W1989798009 cites W2108145540 @default.
• W1989798009 cites W2126568243 @default.
• W1989798009 cites W2166419272 @default.
• W1989798009 cites W4246162114 @default.
• W1989798009 cites W926227776 @default.
• W1989798009 doi "https://doi.org/10.1002/(sici)1098-1136(199805)23:1<35::aid-glia4>3.0.co;2-3" @default.
• W1989798009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9562183" @default.
• W1989798009 hasPublicationYear "1998" @default.
• W1989798009 type Work @default.
• W1989798009 sameAs 1989798009 @default.
• W1989798009 citedByCount "5" @default.
• W1989798009 crossrefType "journal-article" @default.
• W1989798009 hasAuthorship W1989798009A5019632330 @default.
• W1989798009 hasAuthorship W1989798009A5070349543 @default.
• W1989798009 hasAuthorship W1989798009A5089108079 @default.
• W1989798009 hasConcept C121332964 @default.
• W1989798009 hasConcept C121932024 @default.
• W1989798009 hasConcept C12554922 @default.
• W1989798009 hasConcept C147944092 @default.
• W1989798009 hasConcept C160268369 @default.
• W1989798009 hasConcept C169760540 @default.
• W1989798009 hasConcept C170493617 @default.
• W1989798009 hasConcept C181911157 @default.
• W1989798009 hasConcept C185263204 @default.
• W1989798009 hasConcept C189184402 @default.
• W1989798009 hasConcept C26873012 @default.
• W1989798009 hasConcept C2778071365 @default.
• W1989798009 hasConcept C2780019300 @default.
• W1989798009 hasConcept C55493867 @default.
• W1989798009 hasConcept C61174792 @default.
• W1989798009 hasConcept C86803240 @default.
• W1989798009 hasConceptScore W1989798009C121332964 @default.
• W1989798009 hasConceptScore W1989798009C121932024 @default.
• W1989798009 hasConceptScore W1989798009C12554922 @default.
• W1989798009 hasConceptScore W1989798009C147944092 @default.
• W1989798009 hasConceptScore W1989798009C160268369 @default.
• W1989798009 hasConceptScore W1989798009C169760540 @default.
• W1989798009 hasConceptScore W1989798009C170493617 @default.
• W1989798009 hasConceptScore W1989798009C181911157 @default.
• W1989798009 hasConceptScore W1989798009C185263204 @default.
• W1989798009 hasConceptScore W1989798009C189184402 @default.
• W1989798009 hasConceptScore W1989798009C26873012 @default.
• W1989798009 hasConceptScore W1989798009C2778071365 @default.
• W1989798009 hasConceptScore W1989798009C2780019300 @default.
• W1989798009 hasConceptScore W1989798009C55493867 @default.
• W1989798009 hasConceptScore W1989798009C61174792 @default.
• W1989798009 hasConceptScore W1989798009C86803240 @default.
• W1989798009 hasLocation W19897980091 @default.
• W1989798009 hasLocation W19897980092 @default.
• W1989798009 hasOpenAccess W1989798009 @default.
• W1989798009 hasPrimaryLocation W19897980091 @default.
• W1989798009 hasRelatedWork W1979684921 @default.
• W1989798009 hasRelatedWork W1985014785 @default.
• W1989798009 hasRelatedWork W1989798009 @default.
• W1989798009 hasRelatedWork W2016910868 @default.
• W1989798009 hasRelatedWork W2026294888 @default.
• W1989798009 hasRelatedWork W2064149328 @default.
• W1989798009 hasRelatedWork W2071880368 @default.

• next