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• W1989801565 abstract "You have accessJournal of UrologyKidney Cancer: Surgical Therapy V1 Apr 2015MP70-08 PARTIAL NEPHRECTOMY FOR T2 RENAL MASSES: NATIONAL TRENDS AND ONCOLOGIC EFFICACY Shaheen Alanee, Max Nutt, Aaron Moore, Bradley Holland, Danuta Dynda, Andy Wilber, Wiley Jenkins, Ahmed El-Zawahry, and Bradley Schwartz Shaheen AlaneeShaheen Alanee More articles by this author , Max NuttMax Nutt More articles by this author , Aaron MooreAaron Moore More articles by this author , Bradley HollandBradley Holland More articles by this author , Danuta DyndaDanuta Dynda More articles by this author , Andy WilberAndy Wilber More articles by this author , Wiley JenkinsWiley Jenkins More articles by this author , Ahmed El-ZawahryAhmed El-Zawahry More articles by this author , and Bradley SchwartzBradley Schwartz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2533AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Increasing popularity and improved technical feasibility of partial nephrectomy (PN) has encouraged urologists to resect larger renal masses with nephron sparing surgery. The safety profile of PN in T2 renal lesions has yet to be defined. We used the Surveillance, Epidemiology, and End Results (SEER) registry to characterize national practice patterns for the surgical management of patients with renal masses larger than 7 cm in size confined to the kidney, and examined the effect of PN on cancer-specific survival in such patients. METHODS Between 2001 and 2011, 10,259 patients with primary tumor size > 7 cm confined to the kidney (T2) were treated surgically for kidney cancer. The proportion of patients treated with PN was determined and trends were examined using joinpoint analysis, and quantified using the annual percentage change (APC). Multivariate survival models were developed to identify independent determinants of PN use and cancer specific survival following surgical treatment of kidney cancer. All possible interaction terms were tested for survival analysis to isolate patients who were at survival advantage when treated with PN. RESULTS Overall 543 patients (5.29%) were treated with PN vs. 9,716 (94.71%) who underwent radical nephrectomy (TN). For T2 tumors, the use of PN increased progressively between 2001 (5.78%) and 2011 (7.47%) (APC +11.1%, p< 0.05). Male gender, geographic region of treatment (SEER site), year of diagnosis (2006-2011), and disease stage (localized) were independent determinants of increased PN use (all p values < 0.05). Cancer specific mortality was not inferior for patients treated with PN vs. TN (Hazard ratio: 0.683, 95% CI 0.496-0.942). Male gender, diagnosis between 50 and 60 years of age, white race, tumor size > 10 cm, localized disease, and papillary histology were all associated with improved cancer specific survival with PN (all p values < 0.05) CONCLUSIONS There has been a trend towards increasing utilization of PN in the treatment of T2 renal masses over the past decade. Our analysis demonstrates that PN vs. TN for the management of patients with T2 renal masses has no contraindicated effect on cancer specific mortality. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e878 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shaheen Alanee More articles by this author Max Nutt More articles by this author Aaron Moore More articles by this author Bradley Holland More articles by this author Danuta Dynda More articles by this author Andy Wilber More articles by this author Wiley Jenkins More articles by this author Ahmed El-Zawahry More articles by this author Bradley Schwartz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W1989801565 title "MP70-08 PARTIAL NEPHRECTOMY FOR T2 RENAL MASSES: NATIONAL TRENDS AND ONCOLOGIC EFFICACY" @default.
• W1989801565 doi "https://doi.org/10.1016/j.juro.2015.02.2533" @default.
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