FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989807712> ?p ?o ?g. }

• W1989807712 endingPage "116" @default.
• W1989807712 startingPage "110" @default.
• W1989807712 abstract "Stage II colorectal carcinoma is characterized by negative lymph node pathology as determined by conventional microscopic examination. These patients generally do not receive adjuvant therapy although 20%-30% will die from metastatic disease. To determine whether K-ras mutations at codon 12 could be used as a sensitive indicator of occult lymph node metastasis in stage II colon carcinoma, a retrospective study was performed using restriction endonuclease-mediated selective polymerase chain reaction (REMS-PCR) amplification. Of 106 colonic tumors analyzed, 46 were identified as positive for a K12-ras mutation in the primary tumor. Multiple lymph node samples from 38 of these 46 patients were examined by a sensitive nested PCR protocol for the presence of a K12-ras mutation. Of these 38 patients, 14 had 1 or more positive lymph nodes by PCR (37%) and 24 were negative for the mutation (63%). Of the 14 patients with a K12-ras mutation detected in lymph nodes, 8 died of the disease within 5 years (57%) compared to only 4 of the 24 patients with ras-negative lymph nodes (17%). The difference in time to death from disease, stratified using K12-ras status of lymph nodes, was statistically significant (P = 0.036; log-rank test). These results suggest K-ras mutation status of lymph nodes in patients with stage II colon cancer might identify a subgroup of patients who are more likely to develop recurrent and/or metastatic disease and benefit from adjuvant therapy. Larger studies are indicated to determine whether detection of K-ras mutation positivity in histologically negative lymph nodes portends a poor prognosis and to determine whether more aggressive use of adjuvant therapy is warranted." @default.
• W1989807712 created "2016-06-24" @default.
• W1989807712 creator A5004161131 @default.
• W1989807712 creator A5005960864 @default.
• W1989807712 creator A5016377099 @default.
• W1989807712 creator A5021865400 @default.
• W1989807712 creator A5035883173 @default.
• W1989807712 creator A5052582261 @default.
• W1989807712 creator A5060976304 @default.
• W1989807712 creator A5064296075 @default.
• W1989807712 creator A5076538728 @default.
• W1989807712 creator A5077717829 @default.
• W1989807712 date "2001-08-01" @default.
• W1989807712 modified "2023-10-16" @default.
• W1989807712 title "Detection of Mutated K12-ras in Histologically Negative Lymph Nodes as an Indicator of Poor Prognosis in Stage II Colorectal Cancer" @default.
• W1989807712 cites W1491872325 @default.
• W1989807712 cites W1532520688 @default.
• W1989807712 cites W1868339460 @default.
• W1989807712 cites W1995681683 @default.
• W1989807712 cites W2028674917 @default.
• W1989807712 cites W2030952272 @default.
• W1989807712 cites W2058649415 @default.
• W1989807712 cites W2062583598 @default.
• W1989807712 cites W2071697240 @default.
• W1989807712 cites W2091723114 @default.
• W1989807712 cites W2136509556 @default.
• W1989807712 cites W2159966721 @default.
• W1989807712 cites W2339671919 @default.
• W1989807712 cites W4293241248 @default.
• W1989807712 cites W91122573 @default.
• W1989807712 doi "https://doi.org/10.3816/ccc.2001.n.011" @default.
• W1989807712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12445369" @default.
• W1989807712 hasPublicationYear "2001" @default.
• W1989807712 type Work @default.
• W1989807712 sameAs 1989807712 @default.
• W1989807712 citedByCount "34" @default.
• W1989807712 countsByYear W19898077122012 @default.
• W1989807712 countsByYear W19898077122013 @default.
• W1989807712 countsByYear W19898077122015 @default.
• W1989807712 countsByYear W19898077122021 @default.
• W1989807712 crossrefType "journal-article" @default.
• W1989807712 hasAuthorship W1989807712A5004161131 @default.
• W1989807712 hasAuthorship W1989807712A5005960864 @default.
• W1989807712 hasAuthorship W1989807712A5016377099 @default.
• W1989807712 hasAuthorship W1989807712A5021865400 @default.
• W1989807712 hasAuthorship W1989807712A5035883173 @default.
• W1989807712 hasAuthorship W1989807712A5052582261 @default.
• W1989807712 hasAuthorship W1989807712A5060976304 @default.
• W1989807712 hasAuthorship W1989807712A5064296075 @default.
• W1989807712 hasAuthorship W1989807712A5076538728 @default.
• W1989807712 hasAuthorship W1989807712A5077717829 @default.
• W1989807712 hasConcept C104317684 @default.
• W1989807712 hasConcept C121608353 @default.
• W1989807712 hasConcept C126322002 @default.
• W1989807712 hasConcept C142724271 @default.
• W1989807712 hasConcept C143998085 @default.
• W1989807712 hasConcept C146357865 @default.
• W1989807712 hasConcept C151730666 @default.
• W1989807712 hasConcept C2777546739 @default.
• W1989807712 hasConcept C2777982462 @default.
• W1989807712 hasConcept C2779013556 @default.
• W1989807712 hasConcept C2779720271 @default.
• W1989807712 hasConcept C2780849966 @default.
• W1989807712 hasConcept C501734568 @default.
• W1989807712 hasConcept C526805850 @default.
• W1989807712 hasConcept C54355233 @default.
• W1989807712 hasConcept C71924100 @default.
• W1989807712 hasConcept C86803240 @default.
• W1989807712 hasConcept C90924648 @default.
• W1989807712 hasConceptScore W1989807712C104317684 @default.
• W1989807712 hasConceptScore W1989807712C121608353 @default.
• W1989807712 hasConceptScore W1989807712C126322002 @default.
• W1989807712 hasConceptScore W1989807712C142724271 @default.
• W1989807712 hasConceptScore W1989807712C143998085 @default.
• W1989807712 hasConceptScore W1989807712C146357865 @default.
• W1989807712 hasConceptScore W1989807712C151730666 @default.
• W1989807712 hasConceptScore W1989807712C2777546739 @default.
• W1989807712 hasConceptScore W1989807712C2777982462 @default.
• W1989807712 hasConceptScore W1989807712C2779013556 @default.
• W1989807712 hasConceptScore W1989807712C2779720271 @default.
• W1989807712 hasConceptScore W1989807712C2780849966 @default.
• W1989807712 hasConceptScore W1989807712C501734568 @default.
• W1989807712 hasConceptScore W1989807712C526805850 @default.
• W1989807712 hasConceptScore W1989807712C54355233 @default.
• W1989807712 hasConceptScore W1989807712C71924100 @default.
• W1989807712 hasConceptScore W1989807712C86803240 @default.
• W1989807712 hasConceptScore W1989807712C90924648 @default.
• W1989807712 hasIssue "2" @default.
• W1989807712 hasLocation W19898077121 @default.
• W1989807712 hasLocation W19898077122 @default.
• W1989807712 hasOpenAccess W1989807712 @default.
• W1989807712 hasPrimaryLocation W19898077121 @default.
• W1989807712 hasRelatedWork W1966798989 @default.
• W1989807712 hasRelatedWork W1973402430 @default.
• W1989807712 hasRelatedWork W2008553569 @default.
• W1989807712 hasRelatedWork W2020142317 @default.
• W1989807712 hasRelatedWork W2028414386 @default.
• W1989807712 hasRelatedWork W2032187574 @default.

• next