Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989815802> ?p ?o ?g. }
- W1989815802 endingPage "807" @default.
- W1989815802 startingPage "795" @default.
- W1989815802 abstract "Double voltage clamp studies were performed on gap junctions contained in septal membranes of the earthworm median giant axon. The gap junctions exhibited no conductance changes in response to voltages imposed across either the septal membrane or the plasma membrane. However, the trans-septal current displayed a slow (10 s) relaxation in response to transjunctional voltage steps. The experimental evidence suggests that this relaxation is a polarization of the septum due to local accumulation/depletion of permeant ions. A theoretical analysis of this observation suggests that the applied electric field causes accumulation of impermeant anions on one side of the junction and depletion on the other, which leads to a change in concentration of permeant ions to maintain macroscopic electroneutrality. The change in concentration of permeant ions generates a transjunctional equilibrium potential that opposes junctional current flow. These results indicate that currents flowing through gap junctions can have an influence on the distribution of intracellular ions. Moreover, the theoretical analysis suggests that such currents will be accompanied by significant intracellular and intercellular water flow." @default.
- W1989815802 created "2016-06-24" @default.
- W1989815802 creator A5014648021 @default.
- W1989815802 creator A5031408337 @default.
- W1989815802 creator A5065790384 @default.
- W1989815802 creator A5086802858 @default.
- W1989815802 date "1988-05-01" @default.
- W1989815802 modified "2023-09-26" @default.
- W1989815802 title "Steady-state current flow through gap junctions. Effects on intracellular ion concentrations and fluid movement" @default.
- W1989815802 cites W163747120 @default.
- W1989815802 cites W1966386328 @default.
- W1989815802 cites W1991235670 @default.
- W1989815802 cites W2004205861 @default.
- W1989815802 cites W2032771021 @default.
- W1989815802 cites W2051350896 @default.
- W1989815802 cites W2051710352 @default.
- W1989815802 cites W2054652433 @default.
- W1989815802 cites W2067822038 @default.
- W1989815802 cites W2076049099 @default.
- W1989815802 cites W2082456351 @default.
- W1989815802 cites W2088869566 @default.
- W1989815802 cites W2091096601 @default.
- W1989815802 cites W2165599609 @default.
- W1989815802 doi "https://doi.org/10.1016/s0006-3495(88)83159-x" @default.
- W1989815802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1330256" @default.
- W1989815802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3390521" @default.
- W1989815802 hasPublicationYear "1988" @default.
- W1989815802 type Work @default.
- W1989815802 sameAs 1989815802 @default.
- W1989815802 citedByCount "8" @default.
- W1989815802 countsByYear W19898158022018 @default.
- W1989815802 crossrefType "journal-article" @default.
- W1989815802 hasAuthorship W1989815802A5014648021 @default.
- W1989815802 hasAuthorship W1989815802A5031408337 @default.
- W1989815802 hasAuthorship W1989815802A5065790384 @default.
- W1989815802 hasAuthorship W1989815802A5086802858 @default.
- W1989815802 hasBestOaLocation W19898158021 @default.
- W1989815802 hasConcept C121332964 @default.
- W1989815802 hasConcept C121932024 @default.
- W1989815802 hasConcept C12554922 @default.
- W1989815802 hasConcept C145148216 @default.
- W1989815802 hasConcept C147789679 @default.
- W1989815802 hasConcept C148043351 @default.
- W1989815802 hasConcept C158157758 @default.
- W1989815802 hasConcept C170493617 @default.
- W1989815802 hasConcept C178790620 @default.
- W1989815802 hasConcept C181911157 @default.
- W1989815802 hasConcept C185592680 @default.
- W1989815802 hasConcept C26873012 @default.
- W1989815802 hasConcept C41625074 @default.
- W1989815802 hasConcept C50254741 @default.
- W1989815802 hasConcept C55493867 @default.
- W1989815802 hasConcept C79879829 @default.
- W1989815802 hasConcept C8171440 @default.
- W1989815802 hasConcept C86803240 @default.
- W1989815802 hasConcept C97355855 @default.
- W1989815802 hasConcept C99975950 @default.
- W1989815802 hasConceptScore W1989815802C121332964 @default.
- W1989815802 hasConceptScore W1989815802C121932024 @default.
- W1989815802 hasConceptScore W1989815802C12554922 @default.
- W1989815802 hasConceptScore W1989815802C145148216 @default.
- W1989815802 hasConceptScore W1989815802C147789679 @default.
- W1989815802 hasConceptScore W1989815802C148043351 @default.
- W1989815802 hasConceptScore W1989815802C158157758 @default.
- W1989815802 hasConceptScore W1989815802C170493617 @default.
- W1989815802 hasConceptScore W1989815802C178790620 @default.
- W1989815802 hasConceptScore W1989815802C181911157 @default.
- W1989815802 hasConceptScore W1989815802C185592680 @default.
- W1989815802 hasConceptScore W1989815802C26873012 @default.
- W1989815802 hasConceptScore W1989815802C41625074 @default.
- W1989815802 hasConceptScore W1989815802C50254741 @default.
- W1989815802 hasConceptScore W1989815802C55493867 @default.
- W1989815802 hasConceptScore W1989815802C79879829 @default.
- W1989815802 hasConceptScore W1989815802C8171440 @default.
- W1989815802 hasConceptScore W1989815802C86803240 @default.
- W1989815802 hasConceptScore W1989815802C97355855 @default.
- W1989815802 hasConceptScore W1989815802C99975950 @default.
- W1989815802 hasIssue "5" @default.
- W1989815802 hasLocation W19898158021 @default.
- W1989815802 hasLocation W19898158022 @default.
- W1989815802 hasLocation W19898158023 @default.
- W1989815802 hasLocation W19898158024 @default.
- W1989815802 hasOpenAccess W1989815802 @default.
- W1989815802 hasPrimaryLocation W19898158021 @default.
- W1989815802 hasRelatedWork W111279135 @default.
- W1989815802 hasRelatedWork W1992055301 @default.
- W1989815802 hasRelatedWork W1995739806 @default.
- W1989815802 hasRelatedWork W2005731364 @default.
- W1989815802 hasRelatedWork W2013520840 @default.
- W1989815802 hasRelatedWork W2016910868 @default.
- W1989815802 hasRelatedWork W2061348643 @default.
- W1989815802 hasRelatedWork W2063203362 @default.
- W1989815802 hasRelatedWork W2076244849 @default.
- W1989815802 hasRelatedWork W62018354 @default.
- W1989815802 hasVolume "53" @default.
- W1989815802 isParatext "false" @default.
- W1989815802 isRetracted "false" @default.
- W1989815802 magId "1989815802" @default.