Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989832037> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1989832037 endingPage "301" @default.
- W1989832037 startingPage "287" @default.
- W1989832037 abstract "Cancer cells, by releasing pro-angiogenic factors, stimulate the growth of the thick capillary net necessary for the nourishment of the tumor mass. The battle to defeat cancer uses today different approaches based on the inhibition of pathological angiogenesis: several compounds, either synthetic or biotech, aimed at this complex process, are under development. Vascular endothelial growth factor (VEGF) is considered the main target for an anti-cancer therapy based on angiogenesis inhibition; the goal is to block the interaction between this cytokine and its receptors in order to stop the intracellular signaling pathways leading to endothelium remodeling. FDA recently approved two drugs specifically aimed at VEGF, bevacizumab, a humanized monoclonal antibody, and pegaptinib, a pegylated aptamer with application in ophthalmic pathologies. These two approvals validate anti-VEGF therapy for clinical use, and show how biotech companies are investing on angiogenesis using different approaches, i.e. exploiting protein drugs and oligonucleotide-based therapeutics. Monoclonal antibodies, as well as other high molecular weight products like cytokine-traps, aptamers and short interfering RNA (siRNA), are designed to target VEGF and its receptors. Their design, production and clinical advancement in cancer and other pathological conditions linked to angiogenesis will be specifically addressed in this review." @default.
- W1989832037 created "2016-06-24" @default.
- W1989832037 creator A5040276109 @default.
- W1989832037 creator A5088792877 @default.
- W1989832037 date "2006-07-01" @default.
- W1989832037 modified "2023-10-07" @default.
- W1989832037 title "From Proteins to Nucleic Acid-Based Drugs: The Role of Biotech in Anti-VEGF Therapy" @default.
- W1989832037 doi "https://doi.org/10.2174/187152006777698178" @default.
- W1989832037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16842232" @default.
- W1989832037 hasPublicationYear "2006" @default.
- W1989832037 type Work @default.
- W1989832037 sameAs 1989832037 @default.
- W1989832037 citedByCount "16" @default.
- W1989832037 countsByYear W19898320372012 @default.
- W1989832037 countsByYear W19898320372013 @default.
- W1989832037 countsByYear W19898320372014 @default.
- W1989832037 countsByYear W19898320372015 @default.
- W1989832037 countsByYear W19898320372016 @default.
- W1989832037 countsByYear W19898320372020 @default.
- W1989832037 crossrefType "journal-article" @default.
- W1989832037 hasAuthorship W1989832037A5040276109 @default.
- W1989832037 hasAuthorship W1989832037A5088792877 @default.
- W1989832037 hasConcept C121608353 @default.
- W1989832037 hasConcept C126322002 @default.
- W1989832037 hasConcept C128972844 @default.
- W1989832037 hasConcept C153911025 @default.
- W1989832037 hasConcept C159654299 @default.
- W1989832037 hasConcept C167734588 @default.
- W1989832037 hasConcept C203014093 @default.
- W1989832037 hasConcept C2776694085 @default.
- W1989832037 hasConcept C2777025900 @default.
- W1989832037 hasConcept C2777802072 @default.
- W1989832037 hasConcept C2778690821 @default.
- W1989832037 hasConcept C2780394083 @default.
- W1989832037 hasConcept C502942594 @default.
- W1989832037 hasConcept C542903549 @default.
- W1989832037 hasConcept C71924100 @default.
- W1989832037 hasConcept C86803240 @default.
- W1989832037 hasConcept C98274493 @default.
- W1989832037 hasConceptScore W1989832037C121608353 @default.
- W1989832037 hasConceptScore W1989832037C126322002 @default.
- W1989832037 hasConceptScore W1989832037C128972844 @default.
- W1989832037 hasConceptScore W1989832037C153911025 @default.
- W1989832037 hasConceptScore W1989832037C159654299 @default.
- W1989832037 hasConceptScore W1989832037C167734588 @default.
- W1989832037 hasConceptScore W1989832037C203014093 @default.
- W1989832037 hasConceptScore W1989832037C2776694085 @default.
- W1989832037 hasConceptScore W1989832037C2777025900 @default.
- W1989832037 hasConceptScore W1989832037C2777802072 @default.
- W1989832037 hasConceptScore W1989832037C2778690821 @default.
- W1989832037 hasConceptScore W1989832037C2780394083 @default.
- W1989832037 hasConceptScore W1989832037C502942594 @default.
- W1989832037 hasConceptScore W1989832037C542903549 @default.
- W1989832037 hasConceptScore W1989832037C71924100 @default.
- W1989832037 hasConceptScore W1989832037C86803240 @default.
- W1989832037 hasConceptScore W1989832037C98274493 @default.
- W1989832037 hasIssue "4" @default.
- W1989832037 hasLocation W19898320371 @default.
- W1989832037 hasLocation W19898320372 @default.
- W1989832037 hasOpenAccess W1989832037 @default.
- W1989832037 hasPrimaryLocation W19898320371 @default.
- W1989832037 hasRelatedWork W1970773045 @default.
- W1989832037 hasRelatedWork W2033684641 @default.
- W1989832037 hasRelatedWork W2081632393 @default.
- W1989832037 hasRelatedWork W2147509954 @default.
- W1989832037 hasRelatedWork W2333347192 @default.
- W1989832037 hasRelatedWork W2390834423 @default.
- W1989832037 hasRelatedWork W2898457449 @default.
- W1989832037 hasRelatedWork W2913646003 @default.
- W1989832037 hasRelatedWork W2967136651 @default.
- W1989832037 hasRelatedWork W811056451 @default.
- W1989832037 hasVolume "6" @default.
- W1989832037 isParatext "false" @default.
- W1989832037 isRetracted "false" @default.
- W1989832037 magId "1989832037" @default.
- W1989832037 workType "article" @default.