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• W1989836148 abstract "Extracellular ATP activates large increases in cell surface area and membrane turnover in rat brown adipocytes (Pappone, P. A., and Lee, S. C. 1996. J. Gen. Physiol. 108:393–404). We used whole-cell patch clamp membrane capacitance measurements of membrane surface area concurrently with fura-2 ratio imaging of intracellular calcium to test whether these purinergic membrane responses are triggered by cytosolic calcium increases or G protein activation. Increasing cytosolic calcium with adrenergic stimulation, calcium ionophore, or calcium-containing pipette solutions did not cause exocytosis. Extracellular ATP increased membrane capacitance in the absence of extracellular calcium with internal calcium strongly buffered to near resting levels. Purinergic stimulation still activated exocytosis and endocytosis in the complete absence of intracellular and extracellular free calcium, but endocytosis predominated. Modulators of G protein function neither triggered nor inhibited the initial ATP-elicited capacitance changes, but GTPγS or cytosolic nucleotide depletion did reduce the cells’ capacity to mount multiple purinergic responses. These results suggest that calcium modulates purinergically-stimulated membrane trafficking in brown adipocytes, but that ATP responses are initiated by some other signal that remains to be identified." @default.
• W1989836148 created "2016-06-24" @default.
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• W1989836148 date "1999-04-01" @default.
• W1989836148 modified "2023-10-17" @default.
• W1989836148 title "ATP Can Stimulate Exocytosis in Rat Brown Adipocytes without Apparent Increases in Cytosolic Ca2+ or G Protein Activation" @default.
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• W1989836148 doi "https://doi.org/10.1016/s0006-3495(99)77385-6" @default.
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