FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989836638> ?p ?o ?g. }

• W1989836638 endingPage "224" @default.
• W1989836638 startingPage "217" @default.
• W1989836638 abstract "Objective: Urinary bladder hyperplasia associated with terephthalic acid (TPA) treatment was examined with concomitant use of sodium bicarbonate (NaHCO3) or hydrochlorothiazide to allow assessment of the relationship among bladder stones, epithelial hyperplasia, and corresponding cell cycle checkpoint gene expression in Sprague–Dawley (SD) rat. Methods: A total of 112 weanling male SD rats that divided between six groups were given basal diet (control), diets containing 5% TPA or in combination with either 4% sodium NaHCO3 or 0.02% hydrochlorothiazide. After 90-day feeding, bladder samples were collected for histopathological diagnoses, and immunohistochemical method was used to characterize the expression of p16Ink4a, cyclin D1, CDK4, EGFr and cyclin E in relation to that of proliferating cell nuclear antigen (PCNA). Results: In TPA treatment groups, bladder stone incidence was 40% (21/52) with 14 cases of proliferative bladder. In control and other groups, neither stone nor epithelial cell proliferation was diagnosed. PCNA-positive focal hyperplasic lesions involved all epithelial layers. Overexpressions of cyclin D1, CDK4, EGFr are found in the corresponding lesion. p16Ink4a nuclear staining reduced in proliferative bladders especially with a great quantity of stone. In addition, no positive expression was detected on cyclin E. Conclusion: The present study provides a strong evidence of a link between induction of bladder hyperplasia, deregulation of the p16Ink4a-cyclin D1/CDK4 pathway, and abnormal EGFr mediated signal transduction pathway." @default.
• W1989836638 created "2016-06-24" @default.
• W1989836638 creator A5000219612 @default.
• W1989836638 creator A5002935941 @default.
• W1989836638 creator A5051145637 @default.
• W1989836638 creator A5053767699 @default.
• W1989836638 creator A5063305363 @default.
• W1989836638 creator A5063812564 @default.
• W1989836638 creator A5081422038 @default.
• W1989836638 date "2005-02-01" @default.
• W1989836638 modified "2023-10-16" @default.
• W1989836638 title "Bladder epithelial cell proliferation of rats induced by terephthalic acid-calculi" @default.
• W1989836638 cites W1556068352 @default.
• W1989836638 cites W1976936270 @default.
• W1989836638 cites W1989863356 @default.
• W1989836638 cites W2007255413 @default.
• W1989836638 cites W2020031362 @default.
• W1989836638 cites W2022330927 @default.
• W1989836638 cites W2028910227 @default.
• W1989836638 cites W2029207071 @default.
• W1989836638 cites W2037140399 @default.
• W1989836638 cites W2049085719 @default.
• W1989836638 cites W2064913242 @default.
• W1989836638 cites W2065017038 @default.
• W1989836638 cites W2077577898 @default.
• W1989836638 cites W2081034228 @default.
• W1989836638 cites W2081087321 @default.
• W1989836638 cites W2090997163 @default.
• W1989836638 cites W2091664796 @default.
• W1989836638 cites W2097450564 @default.
• W1989836638 cites W2102015080 @default.
• W1989836638 cites W2107535776 @default.
• W1989836638 cites W2114205900 @default.
• W1989836638 cites W2123242519 @default.
• W1989836638 cites W2124275798 @default.
• W1989836638 cites W2130941632 @default.
• W1989836638 cites W2140911476 @default.
• W1989836638 cites W2151729715 @default.
• W1989836638 cites W2994198383 @default.
• W1989836638 doi "https://doi.org/10.1016/j.fct.2004.09.017" @default.
• W1989836638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15621333" @default.
• W1989836638 hasPublicationYear "2005" @default.
• W1989836638 type Work @default.
• W1989836638 sameAs 1989836638 @default.
• W1989836638 citedByCount "16" @default.
• W1989836638 countsByYear W19898366382012 @default.
• W1989836638 countsByYear W19898366382014 @default.
• W1989836638 countsByYear W19898366382016 @default.
• W1989836638 countsByYear W19898366382018 @default.
• W1989836638 crossrefType "journal-article" @default.
• W1989836638 hasAuthorship W1989836638A5000219612 @default.
• W1989836638 hasAuthorship W1989836638A5002935941 @default.
• W1989836638 hasAuthorship W1989836638A5051145637 @default.
• W1989836638 hasAuthorship W1989836638A5053767699 @default.
• W1989836638 hasAuthorship W1989836638A5063305363 @default.
• W1989836638 hasAuthorship W1989836638A5063812564 @default.
• W1989836638 hasAuthorship W1989836638A5081422038 @default.
• W1989836638 hasConcept C11882975 @default.
• W1989836638 hasConcept C121608353 @default.
• W1989836638 hasConcept C126322002 @default.
• W1989836638 hasConcept C126894567 @default.
• W1989836638 hasConcept C142724271 @default.
• W1989836638 hasConcept C199835354 @default.
• W1989836638 hasConcept C204232928 @default.
• W1989836638 hasConcept C2777540882 @default.
• W1989836638 hasConcept C2777562237 @default.
• W1989836638 hasConcept C2779762690 @default.
• W1989836638 hasConcept C2780352672 @default.
• W1989836638 hasConcept C29537977 @default.
• W1989836638 hasConcept C34688535 @default.
• W1989836638 hasConcept C502942594 @default.
• W1989836638 hasConcept C55493867 @default.
• W1989836638 hasConcept C62112901 @default.
• W1989836638 hasConcept C71924100 @default.
• W1989836638 hasConcept C86803240 @default.
• W1989836638 hasConcept C94561458 @default.
• W1989836638 hasConceptScore W1989836638C11882975 @default.
• W1989836638 hasConceptScore W1989836638C121608353 @default.
• W1989836638 hasConceptScore W1989836638C126322002 @default.
• W1989836638 hasConceptScore W1989836638C126894567 @default.
• W1989836638 hasConceptScore W1989836638C142724271 @default.
• W1989836638 hasConceptScore W1989836638C199835354 @default.
• W1989836638 hasConceptScore W1989836638C204232928 @default.
• W1989836638 hasConceptScore W1989836638C2777540882 @default.
• W1989836638 hasConceptScore W1989836638C2777562237 @default.
• W1989836638 hasConceptScore W1989836638C2779762690 @default.
• W1989836638 hasConceptScore W1989836638C2780352672 @default.
• W1989836638 hasConceptScore W1989836638C29537977 @default.
• W1989836638 hasConceptScore W1989836638C34688535 @default.
• W1989836638 hasConceptScore W1989836638C502942594 @default.
• W1989836638 hasConceptScore W1989836638C55493867 @default.
• W1989836638 hasConceptScore W1989836638C62112901 @default.
• W1989836638 hasConceptScore W1989836638C71924100 @default.
• W1989836638 hasConceptScore W1989836638C86803240 @default.
• W1989836638 hasConceptScore W1989836638C94561458 @default.
• W1989836638 hasIssue "2" @default.
• W1989836638 hasLocation W19898366381 @default.
• W1989836638 hasLocation W19898366382 @default.

• next