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- W1989848893 abstract "Six new Ru(II) and Ru(III) complexes have been synthesized and characterized by elemental analysis, LC-MS, electronic spectra, IR spectra and magnetic moment measurements. DNA-binding properties of Ru complexes have been studied by means of absorption spectrophotometry and viscosity measurements as well as their HS DNA cleavage properties by means of agarose gel electrophoresis. The experimental results show that all the complexes can bind to DNA via partial intercalative mode. The K b values of complexes were found in the range 2.14 × 10 4 to 2.70 × 10 5 M−1. All the complexes show excellent efficiency of cleaving DNA than respective fluoroquinolones. Brine shrimp lethality bioassay has been performed to check the cytotoxic activity. The IC 50 values of the complexes are in the range of 6.27 to 16.05 μg mL−1." @default.
- W1989848893 created "2016-06-24" @default.
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- W1989848893 date "2014-05-01" @default.
- W1989848893 modified "2023-09-26" @default.
- W1989848893 title "Cytotoxic, DNA binding, DNA cleavage and antibacterial studies of ruthenium–fluoroquinolone complexes" @default.
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- W1989848893 doi "https://doi.org/10.1007/s12039-014-0597-9" @default.
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