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• W1989849605 abstract "Abstract The adult differentiated insulin-secreting pancreatic islet β-cell experiences slow growth. This study shows that atrial natriuretic peptide (ANP) stimulates cell proliferation and [3H]thymidine incorporation in INS-1E glucose-sensitive rat β-cell line cells and isolated rat islet DNA. In addition, cGMP, the second messenger of natriuretic peptide receptors (NPR) A and B, stimulated islet DNA biosynthesis. The NPR-A receptor was expressed in INS-1E cells and islets. ANP-stimulated INS-1E cell DNA biosynthesis was blocked by preincubation with LY294002 (50 μm), an inhibitor of phosphatidylinositol 3′-kinase (PI3K). An indicator of cell cycle progression, cyclin D2 mRNA was increased by 2- to 3-fold in ANP- or 8-Br-cGMP-treated INS-1E cells and islets, and these responses were inhibited by LY294002. ANP and 8-Br-cGMP stimulated the phosphorylation of Akt and Foxo1a in INS-1E cells and islets, and LY294002 inhibited these responses. In contrast, ANP reduced the levels of phospho-ERK in INS-1E cells. Pancreas duodenum homeobox-1 (PDX-1) is essential for pancreas development, insulin production, and glucose homeostasis, and ANP increased PDX-1 mRNA levels by 2- to 3-fold in INS-1E cells and islets. The levels of glucokinase mRNA in islets and INS-1E cells were also increased in response to ANP. The evidence suggests that pancreatic β-cell NPR-A stimulation results in activation of a growth-promoting signaling pathway that includes PI3K/Akt/Foxo1a/cyclin D2. These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity." @default.
• W1989849605 created "2016-06-24" @default.
• W1989849605 creator A5018361663 @default.
• W1989849605 creator A5031022075 @default.
• W1989849605 date "2009-10-16" @default.
• W1989849605 modified "2023-09-27" @default.
• W1989849605 title "Atrial Natriuretic Peptide Promotes Pancreatic Islet β-Cell Growth and Akt/Foxo1a/Cyclin D2 Signaling" @default.
• W1989849605 cites W1495346616 @default.
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• W1989849605 cites W1968133257 @default.
• W1989849605 cites W1969459168 @default.
• W1989849605 cites W1972087054 @default.
• W1989849605 cites W1974873639 @default.
• W1989849605 cites W1975092580 @default.
• W1989849605 cites W1979905697 @default.
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• W1989849605 doi "https://doi.org/10.1210/en.2009-0468" @default.
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