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- W1989862594 abstract "Classical thinking suggests that the immune system undergoes activation on the basis of discrimination between ‘self’ and ‘non-self’. Accordingly, the fetus activates the mother's immune system because the fetus is in part ‘non-self’. Thus, successful pregnancy depends on constraint of maternal immunity. Preeclampsia is an outcome of lost constraint. Instead, the danger model suggests that normal pregnancy, regardless of the expression of ‘non-self’ antigens, does not activate the maternal immune system unless that pregnancy expresses danger signals. Thus, preeclampsia stems from stress or abnormal cell death in pregnancy-related tissues. This compels expression of specific danger signals and potential activation of anti-fetal immunity, which secondarily feeds the syndrome. Study of preeclampsia from this perspective may bring forth novel mechanisms and indicators of vascular and metabolic dysfunction during pregnancy." @default.
- W1989862594 created "2016-06-24" @default.
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- W1989862594 date "2007-12-01" @default.
- W1989862594 modified "2023-09-27" @default.
- W1989862594 title "Preeclampsia: a view through the danger model" @default.
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- W1989862594 doi "https://doi.org/10.1016/j.jri.2007.03.006" @default.
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