Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989872736> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1989872736 endingPage "S218" @default.
- W1989872736 startingPage "S218" @default.
- W1989872736 abstract "Exosomes are nanovesicles produced in the late endosome and secreted by various cell types, including dendritic cells (DC) and other antigen presenting cells. Studies of tumor-derived exosomes have demonstrated that they are capable of suppressing host anti- tumor immune response and placental-derived exosomes play an important role in establishing maternal immune tolerance toward the fetus. We have demonstrated previously that exosomes derived from DC transfected with adenoviral vectors containing anti- inflammatory molecules such as IL-10, IL-4 and FasL are capable of suppressing antigen-specific immune responses in multiple disease models, such as delayed type hypersensitivity and collagen-induced arthritis. In this study, we examine the ability of DC and DC-derived exosomes to halt the progression of diabetes in the NOD model of autoimmune diabetes. Exosomes were isolated by differential centrifugation from the enriched culture medium of bone marrow derived DC from NOD/LTJ mice transduced with either an adenoviral vector encoding IL-4 or a control empty vector. NOD/LTJ mice were treated via tail vein injection with either the transduced DC or the exosome preparation. The DC transduced with IL-4 were able to prevent the onset of diabetes with a single treatment to either 5- or 10-week old NOD mice, similar to our previous results. Interesting, treatment of NOD/LTJ with DC-derived exosomes also prevented the onset of hyperglycemia. These results suggest that exosomes from immunosuppressive DC are able to block progression of diabetes in NOD mice and thus could be used clinically to treat type I diabetes." @default.
- W1989872736 created "2016-06-24" @default.
- W1989872736 creator A5001857296 @default.
- W1989872736 creator A5039203370 @default.
- W1989872736 creator A5040467127 @default.
- W1989872736 creator A5053100074 @default.
- W1989872736 creator A5061425858 @default.
- W1989872736 creator A5072762727 @default.
- W1989872736 creator A5074835396 @default.
- W1989872736 date "2006-01-01" @default.
- W1989872736 modified "2023-09-27" @default.
- W1989872736 title "566. Delaying the Onset of Diabetes in the NOD Mouse Using Exosomes Derived from Dendritic Cells Transfected with Adenoviral Vectors" @default.
- W1989872736 doi "https://doi.org/10.1016/j.ymthe.2006.08.639" @default.
- W1989872736 hasPublicationYear "2006" @default.
- W1989872736 type Work @default.
- W1989872736 sameAs 1989872736 @default.
- W1989872736 citedByCount "0" @default.
- W1989872736 crossrefType "journal-article" @default.
- W1989872736 hasAuthorship W1989872736A5001857296 @default.
- W1989872736 hasAuthorship W1989872736A5039203370 @default.
- W1989872736 hasAuthorship W1989872736A5040467127 @default.
- W1989872736 hasAuthorship W1989872736A5053100074 @default.
- W1989872736 hasAuthorship W1989872736A5061425858 @default.
- W1989872736 hasAuthorship W1989872736A5072762727 @default.
- W1989872736 hasAuthorship W1989872736A5074835396 @default.
- W1989872736 hasBestOaLocation W19898727361 @default.
- W1989872736 hasConcept C104317684 @default.
- W1989872736 hasConcept C134018914 @default.
- W1989872736 hasConcept C145059251 @default.
- W1989872736 hasConcept C203014093 @default.
- W1989872736 hasConcept C20518536 @default.
- W1989872736 hasConcept C2778013207 @default.
- W1989872736 hasConcept C2778170410 @default.
- W1989872736 hasConcept C2780130043 @default.
- W1989872736 hasConcept C2781261824 @default.
- W1989872736 hasConcept C502942594 @default.
- W1989872736 hasConcept C54009773 @default.
- W1989872736 hasConcept C54355233 @default.
- W1989872736 hasConcept C55493867 @default.
- W1989872736 hasConcept C555293320 @default.
- W1989872736 hasConcept C55851684 @default.
- W1989872736 hasConcept C71924100 @default.
- W1989872736 hasConcept C81885089 @default.
- W1989872736 hasConcept C86803240 @default.
- W1989872736 hasConcept C8891405 @default.
- W1989872736 hasConceptScore W1989872736C104317684 @default.
- W1989872736 hasConceptScore W1989872736C134018914 @default.
- W1989872736 hasConceptScore W1989872736C145059251 @default.
- W1989872736 hasConceptScore W1989872736C203014093 @default.
- W1989872736 hasConceptScore W1989872736C20518536 @default.
- W1989872736 hasConceptScore W1989872736C2778013207 @default.
- W1989872736 hasConceptScore W1989872736C2778170410 @default.
- W1989872736 hasConceptScore W1989872736C2780130043 @default.
- W1989872736 hasConceptScore W1989872736C2781261824 @default.
- W1989872736 hasConceptScore W1989872736C502942594 @default.
- W1989872736 hasConceptScore W1989872736C54009773 @default.
- W1989872736 hasConceptScore W1989872736C54355233 @default.
- W1989872736 hasConceptScore W1989872736C55493867 @default.
- W1989872736 hasConceptScore W1989872736C555293320 @default.
- W1989872736 hasConceptScore W1989872736C55851684 @default.
- W1989872736 hasConceptScore W1989872736C71924100 @default.
- W1989872736 hasConceptScore W1989872736C81885089 @default.
- W1989872736 hasConceptScore W1989872736C86803240 @default.
- W1989872736 hasConceptScore W1989872736C8891405 @default.
- W1989872736 hasLocation W19898727361 @default.
- W1989872736 hasOpenAccess W1989872736 @default.
- W1989872736 hasPrimaryLocation W19898727361 @default.
- W1989872736 hasRelatedWork W1946983739 @default.
- W1989872736 hasRelatedWork W2371334415 @default.
- W1989872736 hasRelatedWork W2518911426 @default.
- W1989872736 hasRelatedWork W2520300236 @default.
- W1989872736 hasRelatedWork W2804840825 @default.
- W1989872736 hasRelatedWork W3048286913 @default.
- W1989872736 hasRelatedWork W4285095339 @default.
- W1989872736 hasRelatedWork W4313383814 @default.
- W1989872736 hasRelatedWork W964806462 @default.
- W1989872736 hasRelatedWork W2188794403 @default.
- W1989872736 hasVolume "13" @default.
- W1989872736 isParatext "false" @default.
- W1989872736 isRetracted "false" @default.
- W1989872736 magId "1989872736" @default.
- W1989872736 workType "article" @default.