FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989872783> ?p ?o ?g. }

• W1989872783 endingPage "1284" @default.
• W1989872783 startingPage "1278" @default.
• W1989872783 abstract "Background. Brain death-related cardiovascular dysfunction has been documented; however, its mechanisms remain poorly understood. We investigated changes in myocardial function and metabolism in brain-dead and control pigs. Methods. Heart rate, systolic (SAP) and mean (MAP) arterial pressure, left ventricular (LV) dP/dtmax, rate-pressure product, cardiac output (CO), left anterior descending coronary artery blood flow, lactate metabolism, and interstitial myocardial purine metabolite concentrations, monitored by cardiac microdialysis, were studied. A volume expansion protocol was performed at the end of the study. Results. After brain death, a transient increase in heart rate (from 90 [67-120] to 158 [120-200] beats/min) (median, with range in brackets), MAP (82 [74-103] to 117 [85-142] mmHg), LV dP/dtmax (1750 [1100-2100] to 5150 [4000-62,000] mmHg·sec-1), rate-pressure product (9100 [7700-9700] beats mmHg/min to 22,750 [20,000-26,000] beats mmHg/min), CO (2.2 [2.0-4.0] to 3.3 [3.0-6.0] L/min), and a limited increase in left anterior descending coronary artery blood flow (40 [30-60] to 72 [50-85] ml/min) were observed. Net myocardial lactate production occurred (27 [4-40] to -22 [-28, -11] mg/L, P<0.05) and persisted for 2 hr. A 6-7-fold increase in adenosine dialysate concentration was observed after brain death induction (2.9 [1.0-5.8] to 15.8 [7.0-50.7] µmol/L), followed by a slow decline. Volume expansion significantly increased MAP, CO, and LV dP/dtmax in control animals, but decreased LV dP/dtmax and slightly increased CO in brain-dead animals. A significant increase in adenosine concentration was observed in both groups, with higher levels (P<0.05) in brain-dead animals. Conclusions. Brain death increased oxygen demand in the presence of a limited increase in coronary blood flow, resulting in net myocardial lactate production and increased interstitial adenosine concentration consistent with an imbalance between myocardial oxygen demand and supply. This may have contributed to the early impairment of cardiac function in brain-dead animals revealed by rapid volume infusion." @default.
• W1989872783 created "2016-06-24" @default.
• W1989872783 creator A5008990931 @default.
• W1989872783 creator A5022526104 @default.
• W1989872783 creator A5023687827 @default.
• W1989872783 creator A5052329481 @default.
• W1989872783 creator A5055004014 @default.
• W1989872783 creator A5056338050 @default.
• W1989872783 creator A5061763300 @default.
• W1989872783 creator A5081702250 @default.
• W1989872783 creator A5082291816 @default.
• W1989872783 date "1998-11-01" @default.
• W1989872783 modified "2023-10-17" @default.
• W1989872783 title "INCREASE IN MYOCARDIAL INTERSTITIAL ADENOSINE AND NET LACTATE PRODUCTION IN BRAIN-DEAD PIGS" @default.
• W1989872783 cites W1906305495 @default.
• W1989872783 cites W1967611407 @default.
• W1989872783 cites W1970545385 @default.
• W1989872783 cites W1989692828 @default.
• W1989872783 cites W1990166821 @default.
• W1989872783 cites W1997260873 @default.
• W1989872783 cites W1999833688 @default.
• W1989872783 cites W2007300848 @default.
• W1989872783 cites W2022350424 @default.
• W1989872783 cites W2027180342 @default.
• W1989872783 cites W2028362476 @default.
• W1989872783 cites W2035221143 @default.
• W1989872783 cites W2047649377 @default.
• W1989872783 cites W2051975549 @default.
• W1989872783 cites W2063464624 @default.
• W1989872783 cites W2076610358 @default.
• W1989872783 cites W2091433239 @default.
• W1989872783 cites W2092711749 @default.
• W1989872783 cites W2114033274 @default.
• W1989872783 cites W2157156552 @default.
• W1989872783 cites W2419392669 @default.
• W1989872783 cites W4252973354 @default.
• W1989872783 doi "https://doi.org/10.1097/00007890-199811270-00003" @default.
• W1989872783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9846509" @default.
• W1989872783 hasPublicationYear "1998" @default.
• W1989872783 type Work @default.
• W1989872783 sameAs 1989872783 @default.
• W1989872783 citedByCount "22" @default.
• W1989872783 countsByYear W19898727832012 @default.
• W1989872783 countsByYear W19898727832014 @default.
• W1989872783 countsByYear W19898727832016 @default.
• W1989872783 countsByYear W19898727832019 @default.
• W1989872783 crossrefType "journal-article" @default.
• W1989872783 hasAuthorship W1989872783A5008990931 @default.
• W1989872783 hasAuthorship W1989872783A5022526104 @default.
• W1989872783 hasAuthorship W1989872783A5023687827 @default.
• W1989872783 hasAuthorship W1989872783A5052329481 @default.
• W1989872783 hasAuthorship W1989872783A5055004014 @default.
• W1989872783 hasAuthorship W1989872783A5056338050 @default.
• W1989872783 hasAuthorship W1989872783A5061763300 @default.
• W1989872783 hasAuthorship W1989872783A5081702250 @default.
• W1989872783 hasAuthorship W1989872783A5082291816 @default.
• W1989872783 hasBestOaLocation W19898727831 @default.
• W1989872783 hasConcept C126322002 @default.
• W1989872783 hasConcept C139940330 @default.
• W1989872783 hasConcept C158846371 @default.
• W1989872783 hasConcept C164705383 @default.
• W1989872783 hasConcept C2776452961 @default.
• W1989872783 hasConcept C2776991684 @default.
• W1989872783 hasConcept C2777953023 @default.
• W1989872783 hasConcept C50156730 @default.
• W1989872783 hasConcept C513476851 @default.
• W1989872783 hasConcept C71316499 @default.
• W1989872783 hasConcept C71924100 @default.
• W1989872783 hasConcept C84393581 @default.
• W1989872783 hasConceptScore W1989872783C126322002 @default.
• W1989872783 hasConceptScore W1989872783C139940330 @default.
• W1989872783 hasConceptScore W1989872783C158846371 @default.
• W1989872783 hasConceptScore W1989872783C164705383 @default.
• W1989872783 hasConceptScore W1989872783C2776452961 @default.
• W1989872783 hasConceptScore W1989872783C2776991684 @default.
• W1989872783 hasConceptScore W1989872783C2777953023 @default.
• W1989872783 hasConceptScore W1989872783C50156730 @default.
• W1989872783 hasConceptScore W1989872783C513476851 @default.
• W1989872783 hasConceptScore W1989872783C71316499 @default.
• W1989872783 hasConceptScore W1989872783C71924100 @default.
• W1989872783 hasConceptScore W1989872783C84393581 @default.
• W1989872783 hasIssue "10" @default.
• W1989872783 hasLocation W19898727831 @default.
• W1989872783 hasLocation W19898727832 @default.
• W1989872783 hasLocation W19898727833 @default.
• W1989872783 hasOpenAccess W1989872783 @default.
• W1989872783 hasPrimaryLocation W19898727831 @default.
• W1989872783 hasRelatedWork W1997091388 @default.
• W1989872783 hasRelatedWork W2013824670 @default.
• W1989872783 hasRelatedWork W2093346357 @default.
• W1989872783 hasRelatedWork W2125838186 @default.
• W1989872783 hasRelatedWork W2129708432 @default.
• W1989872783 hasRelatedWork W2376111145 @default.
• W1989872783 hasRelatedWork W2416094913 @default.
• W1989872783 hasRelatedWork W2518842539 @default.
• W1989872783 hasRelatedWork W2739149030 @default.
• W1989872783 hasRelatedWork W963082253 @default.
• W1989872783 hasVolume "66" @default.

• next