FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989875371> ?p ?o ?g. }

• W1989875371 endingPage "384" @default.
• W1989875371 startingPage "378" @default.
• W1989875371 abstract "Cumulating evidence has demonstrated that μ opioid receptor (MOR) agonists promote spinal glial activation, lead to synthesis and release of proinflammatory cytokines and chemokines, and contribute to opioid-induced hyperalgesia and development of opioid tolerance and dependence. However, whether these MOR agonists directly or indirectly act on spinal cord astrocytes and microglial cells in vivo is unclear. In the present study, by combining the techniques of in-situ hybridization of MOR mRNA with immunohistochemistry of glial fibrillary acidic protein (GFAP; an astrocyte marker) and Iba1 (a microglial marker), we examined expression and distribution of GFAP, Iba1, and MOR mRNA in the spinal cord of rats under chronic morphine tolerance conditions. Intrathecal injections of morphine twice daily for 7 days reduced morphine analgesic effect and increased both GFAP and Iba1 immunostaining densities in the spinal cord. Surprisingly, neither GFAP nor Iba1 colocalized with MOR mRNA in spinal cord cells. Our findings indicate that MOR expression is absent from spinal cord astrocytes and microglia, suggesting that these cell types are indirectly activated by MOR agonists under chronic opioid tolerance conditions." @default.
• W1989875371 created "2016-06-24" @default.
• W1989875371 creator A5012015053 @default.
• W1989875371 creator A5013838174 @default.
• W1989875371 creator A5044234498 @default.
• W1989875371 creator A5053395830 @default.
• W1989875371 creator A5076709596 @default.
• W1989875371 creator A5083825774 @default.
• W1989875371 creator A5086332857 @default.
• W1989875371 date "2012-04-18" @default.
• W1989875371 modified "2023-10-14" @default.
• W1989875371 title "Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord" @default.
• W1989875371 cites W142954314 @default.
• W1989875371 cites W1974191568 @default.
• W1989875371 cites W2002737496 @default.
• W1989875371 cites W2003867864 @default.
• W1989875371 cites W2005370375 @default.
• W1989875371 cites W2032174733 @default.
• W1989875371 cites W2038990149 @default.
• W1989875371 cites W2047961059 @default.
• W1989875371 cites W2049628760 @default.
• W1989875371 cites W2058713047 @default.
• W1989875371 cites W2060146354 @default.
• W1989875371 cites W2060932357 @default.
• W1989875371 cites W2065950517 @default.
• W1989875371 cites W2067649367 @default.
• W1989875371 cites W2070158337 @default.
• W1989875371 cites W2084424347 @default.
• W1989875371 cites W2104569716 @default.
• W1989875371 cites W2116947542 @default.
• W1989875371 cites W2467013121 @default.
• W1989875371 doi "https://doi.org/10.1097/wnr.0b013e3283522e1b" @default.
• W1989875371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315618" @default.
• W1989875371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22362187" @default.
• W1989875371 hasPublicationYear "2012" @default.
• W1989875371 type Work @default.
• W1989875371 sameAs 1989875371 @default.
• W1989875371 citedByCount "44" @default.
• W1989875371 countsByYear W19898753712012 @default.
• W1989875371 countsByYear W19898753712013 @default.
• W1989875371 countsByYear W19898753712014 @default.
• W1989875371 countsByYear W19898753712015 @default.
• W1989875371 countsByYear W19898753712017 @default.
• W1989875371 countsByYear W19898753712018 @default.
• W1989875371 countsByYear W19898753712019 @default.
• W1989875371 countsByYear W19898753712020 @default.
• W1989875371 countsByYear W19898753712021 @default.
• W1989875371 countsByYear W19898753712022 @default.
• W1989875371 countsByYear W19898753712023 @default.
• W1989875371 crossrefType "journal-article" @default.
• W1989875371 hasAuthorship W1989875371A5012015053 @default.
• W1989875371 hasAuthorship W1989875371A5013838174 @default.
• W1989875371 hasAuthorship W1989875371A5044234498 @default.
• W1989875371 hasAuthorship W1989875371A5053395830 @default.
• W1989875371 hasAuthorship W1989875371A5076709596 @default.
• W1989875371 hasAuthorship W1989875371A5083825774 @default.
• W1989875371 hasAuthorship W1989875371A5086332857 @default.
• W1989875371 hasBestOaLocation W19898753712 @default.
• W1989875371 hasConcept C104317684 @default.
• W1989875371 hasConcept C126322002 @default.
• W1989875371 hasConcept C134018914 @default.
• W1989875371 hasConcept C150194340 @default.
• W1989875371 hasConcept C15490471 @default.
• W1989875371 hasConcept C164027704 @default.
• W1989875371 hasConcept C169760540 @default.
• W1989875371 hasConcept C170493617 @default.
• W1989875371 hasConcept C204232928 @default.
• W1989875371 hasConcept C2776914184 @default.
• W1989875371 hasConcept C2777542381 @default.
• W1989875371 hasConcept C2779245659 @default.
• W1989875371 hasConcept C2779830541 @default.
• W1989875371 hasConcept C2779886867 @default.
• W1989875371 hasConcept C2780495277 @default.
• W1989875371 hasConcept C2780775167 @default.
• W1989875371 hasConcept C2780884517 @default.
• W1989875371 hasConcept C2781063702 @default.
• W1989875371 hasConcept C4224716 @default.
• W1989875371 hasConcept C529278444 @default.
• W1989875371 hasConcept C55493867 @default.
• W1989875371 hasConcept C71924100 @default.
• W1989875371 hasConcept C81439078 @default.
• W1989875371 hasConcept C86803240 @default.
• W1989875371 hasConceptScore W1989875371C104317684 @default.
• W1989875371 hasConceptScore W1989875371C126322002 @default.
• W1989875371 hasConceptScore W1989875371C134018914 @default.
• W1989875371 hasConceptScore W1989875371C150194340 @default.
• W1989875371 hasConceptScore W1989875371C15490471 @default.
• W1989875371 hasConceptScore W1989875371C164027704 @default.
• W1989875371 hasConceptScore W1989875371C169760540 @default.
• W1989875371 hasConceptScore W1989875371C170493617 @default.
• W1989875371 hasConceptScore W1989875371C204232928 @default.
• W1989875371 hasConceptScore W1989875371C2776914184 @default.
• W1989875371 hasConceptScore W1989875371C2777542381 @default.
• W1989875371 hasConceptScore W1989875371C2779245659 @default.
• W1989875371 hasConceptScore W1989875371C2779830541 @default.
• W1989875371 hasConceptScore W1989875371C2779886867 @default.
• W1989875371 hasConceptScore W1989875371C2780495277 @default.
• W1989875371 hasConceptScore W1989875371C2780775167 @default.

• next