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- W1989877472 abstract "The objective of this study was to examine the expression of the c-raf-1 and A-rat-1 protooncogenes during differentiation of 3T3-L1 preadipocytes into adipocytes. At confluence, prior to initiation of differentiation c-raf and A-raf steady state mRNA levels were low. Expression of c-raf and A-raf began to increase 72 hours following initiation of differentiation by treatment with differentiation medium, reaching a maximum increase of 3 to 6-fold and 3 to 4-fold respectively by 190 hours. The increase of c-raf and A-raf steady state message levels occurred concomitant with the onset of differentiation as indicated by increased levels of glycerol-3-phosphate dehydrogenase mRNA. These changes were compared with those for several other protooncogene mRNAs including c-myc, c-fos, H-ras and histone H3. These results are the first to show increase expression of the raf protooncogenes during terminal differentiation rather than in association with proliferation." @default.
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- W1989877472 date "1989-08-01" @default.
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- W1989877472 title "Expression of c-raf-1 and A-raf-1 during differentiation of 3T3-L1 preadipocyte fibroblasts into adipocytes" @default.
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- W1989877472 doi "https://doi.org/10.1016/0006-291x(89)90798-5" @default.
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