Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989879076> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1989879076 abstract "Photodynamic therapy (PDT) elicits a strong acute inflammatory response that has both local and systemic (acute phase response) attributes. The insult mediated by PDT-induced oxidative stress at the targeted site triggers a complex multifactorial response engaging host defence mechanisms associated with the inflammatory process to participate in the eradication of the treated tumor. Inflammatory cytokines are important mediators of critical events in this process as they regulate the activity of inflammatory, endothelial and other cells. The initial stimulus for enhanced production and release of cytokines likely originates from several types of events, such as activated transcription factors and complement deposition. The PDT-induced complement activation appears to be directly linked to the enhanced expression of various cytokines, including chemokines such as KC (in mouse models), and classic inflammatory cytokines such as IL-1β, TNF-α , IL-6 and IL-10. A variety of interventions that modulate the activity of particular cytokines performed in conjunction with PDT were shown to influence the therapy outcome. The treatments such as using blocking antibodies and local or systemic cytokine delivery may either reduce or dramatically improve the curative effect of PDT. The inflammatory and related cytokines that at present appear particularly interesting and merit further investigation for use as adjuvants to PDT are IL-3, IL-8, IL-15, TNF-α, IFN-γ, G-CSF and GM-CSF." @default.
- W1989879076 created "2016-06-24" @default.
- W1989879076 creator A5004793531 @default.
- W1989879076 creator A5004929327 @default.
- W1989879076 creator A5027237312 @default.
- W1989879076 creator A5058784732 @default.
- W1989879076 date "2001-04-09" @default.
- W1989879076 modified "2023-09-23" @default.
- W1989879076 title "Role of inflammatory cytokines in the response of solid cancers to photodynamic therapy" @default.
- W1989879076 doi "https://doi.org/10.1117/12.424442" @default.
- W1989879076 hasPublicationYear "2001" @default.
- W1989879076 type Work @default.
- W1989879076 sameAs 1989879076 @default.
- W1989879076 citedByCount "2" @default.
- W1989879076 crossrefType "proceedings-article" @default.
- W1989879076 hasAuthorship W1989879076A5004793531 @default.
- W1989879076 hasAuthorship W1989879076A5004929327 @default.
- W1989879076 hasAuthorship W1989879076A5027237312 @default.
- W1989879076 hasAuthorship W1989879076A5058784732 @default.
- W1989879076 hasConcept C101666144 @default.
- W1989879076 hasConcept C110015553 @default.
- W1989879076 hasConcept C13373296 @default.
- W1989879076 hasConcept C164027704 @default.
- W1989879076 hasConcept C178790620 @default.
- W1989879076 hasConcept C17991360 @default.
- W1989879076 hasConcept C185592680 @default.
- W1989879076 hasConcept C203014093 @default.
- W1989879076 hasConcept C2776914184 @default.
- W1989879076 hasConcept C2778690821 @default.
- W1989879076 hasConcept C2781323092 @default.
- W1989879076 hasConcept C502942594 @default.
- W1989879076 hasConcept C71924100 @default.
- W1989879076 hasConcept C8891405 @default.
- W1989879076 hasConceptScore W1989879076C101666144 @default.
- W1989879076 hasConceptScore W1989879076C110015553 @default.
- W1989879076 hasConceptScore W1989879076C13373296 @default.
- W1989879076 hasConceptScore W1989879076C164027704 @default.
- W1989879076 hasConceptScore W1989879076C178790620 @default.
- W1989879076 hasConceptScore W1989879076C17991360 @default.
- W1989879076 hasConceptScore W1989879076C185592680 @default.
- W1989879076 hasConceptScore W1989879076C203014093 @default.
- W1989879076 hasConceptScore W1989879076C2776914184 @default.
- W1989879076 hasConceptScore W1989879076C2778690821 @default.
- W1989879076 hasConceptScore W1989879076C2781323092 @default.
- W1989879076 hasConceptScore W1989879076C502942594 @default.
- W1989879076 hasConceptScore W1989879076C71924100 @default.
- W1989879076 hasConceptScore W1989879076C8891405 @default.
- W1989879076 hasLocation W19898790761 @default.
- W1989879076 hasOpenAccess W1989879076 @default.
- W1989879076 hasPrimaryLocation W19898790761 @default.
- W1989879076 hasRelatedWork W1681866444 @default.
- W1989879076 hasRelatedWork W1978281312 @default.
- W1989879076 hasRelatedWork W199655548 @default.
- W1989879076 hasRelatedWork W2035950972 @default.
- W1989879076 hasRelatedWork W2046004985 @default.
- W1989879076 hasRelatedWork W2073341952 @default.
- W1989879076 hasRelatedWork W2080767539 @default.
- W1989879076 hasRelatedWork W2093748429 @default.
- W1989879076 hasRelatedWork W2246057113 @default.
- W1989879076 hasRelatedWork W2344761035 @default.
- W1989879076 hasRelatedWork W2387402481 @default.
- W1989879076 hasRelatedWork W2793377469 @default.
- W1989879076 hasRelatedWork W2793705639 @default.
- W1989879076 hasRelatedWork W2886658940 @default.
- W1989879076 hasRelatedWork W2917332533 @default.
- W1989879076 hasRelatedWork W3000326517 @default.
- W1989879076 hasRelatedWork W3083746347 @default.
- W1989879076 hasRelatedWork W3143657138 @default.
- W1989879076 hasRelatedWork W6106747 @default.
- W1989879076 hasRelatedWork W2394784667 @default.
- W1989879076 isParatext "false" @default.
- W1989879076 isRetracted "false" @default.
- W1989879076 magId "1989879076" @default.
- W1989879076 workType "article" @default.