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- W1989879946 abstract "β-catenin plays a central role in cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway. Change in β-catenin distribution has been associated with several human cancers including salivary gland tumors. We studied the immunolocalization of β-catenin in a series of pleomorphic adenomas (PA) and carcinomas ex-pleomorphic adenomas (Ca ex-PA). Ten samples of PA and ten of Ca ex-PA were evaluated by immunohistochemistry using streptavidin-biotin-peroxidase technique and a monoclonal antibody against β-catenin (E-5). Cell membrane/cytoplasmic staining of β-catenin was observed in normal gland parenchyma, PA, and in well-differentiated Ca ex-PA. Cytoplasmic/nuclear β-catenin staining was observed in poorly differentiated carcinomas and, interestingly, in one case of PA. Our data showed decreased cell membrane β-catenin expression in higher-grade tumors suggesting that β-catenin may play an important role in histologic differentiation and transition to malignant phenotype of Ca ex-PA." @default.
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- W1989879946 date "2007-09-01" @default.
- W1989879946 modified "2023-09-23" @default.
- W1989879946 title "Immunolocalization of β-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands" @default.
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- W1989879946 doi "https://doi.org/10.1097/01.pai.0000213123.04215.95" @default.
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