Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989887382> ?p ?o ?g. }
- W1989887382 endingPage "78" @default.
- W1989887382 startingPage "69" @default.
- W1989887382 abstract "<b><i>Background:</i></b> New strategies aiming to treat Parkinson’s disease, such as delivery of trophic factors via protein infusion or gene transfer, depend upon localized intracerebral infusion, mainly into the putamen nucleus. Convection-enhanced delivery (CED) has been proposed as a method to improve intracerebral distribution of therapies. Yet analysis of controversial results during the clinical translation of these strategies suggests that intracerebral misdistribution of infusate may have affected the outcomes by limiting the amount of treatment into the target region. <b><i>Objectives:</i></b> This study aimed to identify possible pathways of infusate loss and their relative impact in the success of targeted CED into the postcommissural ventral putamen nucleus. <b><i>Methods:</i></b> Thirteen adult macaque monkeys received intraputaminal CED infusions of 100 µl of 2.0 m<smlcap>M</smlcap> gadoteridol and bromophenol blue (0.16 mg/ml) solution at a rate of 1.0 µl/min under intraoperative magnetic resonance imaging (MRI) guidance. Quantitative maps of infusate concentration were computed at 10-min intervals throughout the procedure in a 3-Tesla MRI scanner. The fraction of tracer lost from the putamen as well as the path of loss were evaluated and quantified for each infusion. <b><i>Results:</i></b> All injections (total 22) were successfully placed in the ventral postcommissural putamen nucleus. Four major paths of infusate loss from the putamen were observed: <i>overflow</i> across putamen boundaries, <i>perivascular flow</i> along large blood vessels, <i>backflow</i> along the inserted catheter and <i>catheter tract leakage</i> into the vacated catheter tract upon catheter removal. Overflow loss was observed within the first 30 µl of infusion in all cases. Measurable tracer loss following the path of an artery out of the putamen was observed in 15 cases, and in 8 of these cases, the loss was greater than 10% of infusate. Backflow that exited the putamen was observed in 4 cases and led to large loss of infusate (80% in 1 case) into the corona radiata. Loss into the vacated catheter tract amounted only to a few microliters. <b><i>Conclusions:</i></b> Our analysis demonstrates that after controlling for targeting, catheter type, infusion rate and infusate, the main issues during surgical planning are the identification of appropriate infusate volume that matches the target area, as well as mapping the regional vasculature as it may become a pathway for infusate loss. Most importantly, these results underscore the significance of presurgical planning for catheter placement and infusion, and the value of imaging guidance to ensure targeting accuracy." @default.
- W1989887382 created "2016-06-24" @default.
- W1989887382 creator A5003352663 @default.
- W1989887382 creator A5029521254 @default.
- W1989887382 creator A5030815730 @default.
- W1989887382 creator A5032465628 @default.
- W1989887382 creator A5052801688 @default.
- W1989887382 creator A5071425444 @default.
- W1989887382 date "2013-01-01" @default.
- W1989887382 modified "2023-10-16" @default.
- W1989887382 title "Pathways of Infusate Loss during Convection-Enhanced Delivery into the Putamen Nucleus" @default.
- W1989887382 cites W1510320707 @default.
- W1989887382 cites W1660607775 @default.
- W1989887382 cites W1968245867 @default.
- W1989887382 cites W1978506065 @default.
- W1989887382 cites W1981497654 @default.
- W1989887382 cites W1985720941 @default.
- W1989887382 cites W1991208841 @default.
- W1989887382 cites W2043160636 @default.
- W1989887382 cites W2043227190 @default.
- W1989887382 cites W2047853664 @default.
- W1989887382 cites W2048303811 @default.
- W1989887382 cites W2049362221 @default.
- W1989887382 cites W2088638034 @default.
- W1989887382 cites W2103899142 @default.
- W1989887382 cites W2107155103 @default.
- W1989887382 cites W2135062838 @default.
- W1989887382 cites W2135907949 @default.
- W1989887382 cites W2145945239 @default.
- W1989887382 cites W2149731696 @default.
- W1989887382 cites W2152609926 @default.
- W1989887382 cites W2156202012 @default.
- W1989887382 cites W2161093026 @default.
- W1989887382 cites W2165526364 @default.
- W1989887382 cites W2181569653 @default.
- W1989887382 cites W2280420202 @default.
- W1989887382 cites W2334461448 @default.
- W1989887382 doi "https://doi.org/10.1159/000342492" @default.
- W1989887382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3716010" @default.
- W1989887382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23344643" @default.
- W1989887382 hasPublicationYear "2013" @default.
- W1989887382 type Work @default.
- W1989887382 sameAs 1989887382 @default.
- W1989887382 citedByCount "35" @default.
- W1989887382 countsByYear W19898873822013 @default.
- W1989887382 countsByYear W19898873822014 @default.
- W1989887382 countsByYear W19898873822015 @default.
- W1989887382 countsByYear W19898873822016 @default.
- W1989887382 countsByYear W19898873822017 @default.
- W1989887382 countsByYear W19898873822018 @default.
- W1989887382 countsByYear W19898873822019 @default.
- W1989887382 countsByYear W19898873822020 @default.
- W1989887382 countsByYear W19898873822021 @default.
- W1989887382 countsByYear W19898873822022 @default.
- W1989887382 countsByYear W19898873822023 @default.
- W1989887382 crossrefType "journal-article" @default.
- W1989887382 hasAuthorship W1989887382A5003352663 @default.
- W1989887382 hasAuthorship W1989887382A5029521254 @default.
- W1989887382 hasAuthorship W1989887382A5030815730 @default.
- W1989887382 hasAuthorship W1989887382A5032465628 @default.
- W1989887382 hasAuthorship W1989887382A5052801688 @default.
- W1989887382 hasAuthorship W1989887382A5071425444 @default.
- W1989887382 hasBestOaLocation W19898873821 @default.
- W1989887382 hasConcept C126322002 @default.
- W1989887382 hasConcept C126838900 @default.
- W1989887382 hasConcept C143409427 @default.
- W1989887382 hasConcept C185592680 @default.
- W1989887382 hasConcept C2779714222 @default.
- W1989887382 hasConcept C2781423529 @default.
- W1989887382 hasConcept C2989005 @default.
- W1989887382 hasConcept C71924100 @default.
- W1989887382 hasConceptScore W1989887382C126322002 @default.
- W1989887382 hasConceptScore W1989887382C126838900 @default.
- W1989887382 hasConceptScore W1989887382C143409427 @default.
- W1989887382 hasConceptScore W1989887382C185592680 @default.
- W1989887382 hasConceptScore W1989887382C2779714222 @default.
- W1989887382 hasConceptScore W1989887382C2781423529 @default.
- W1989887382 hasConceptScore W1989887382C2989005 @default.
- W1989887382 hasConceptScore W1989887382C71924100 @default.
- W1989887382 hasIssue "2" @default.
- W1989887382 hasLocation W19898873821 @default.
- W1989887382 hasLocation W19898873822 @default.
- W1989887382 hasLocation W19898873823 @default.
- W1989887382 hasLocation W19898873824 @default.
- W1989887382 hasOpenAccess W1989887382 @default.
- W1989887382 hasPrimaryLocation W19898873821 @default.
- W1989887382 hasRelatedWork W1930895061 @default.
- W1989887382 hasRelatedWork W2006375474 @default.
- W1989887382 hasRelatedWork W2009372477 @default.
- W1989887382 hasRelatedWork W2254048959 @default.
- W1989887382 hasRelatedWork W2264190293 @default.
- W1989887382 hasRelatedWork W2410033038 @default.
- W1989887382 hasRelatedWork W3033444890 @default.
- W1989887382 hasRelatedWork W3121999164 @default.
- W1989887382 hasRelatedWork W3175863470 @default.
- W1989887382 hasRelatedWork W34930249 @default.
- W1989887382 hasVolume "91" @default.
- W1989887382 isParatext "false" @default.