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- W1989888276 abstract "An oxygen carrier was prepared by encapsulating carbonylated hemoglobin (CO-Hb) molecules into polypeptide vesicles made from poly(l-lysine)-block-poly(l-phenylalanine) (PLL-b-PPA) diblock copolymers in aqueous medium at pH 5.8. The encapsulation was confirmed by confocal laser scanning microscopy (CLSM). The morphology and size of the vesicles were studied by field-emission scanning electron microscopy (ESEM). They had a spherical shape with a mean diameter of about 4 to 5 μm. The encapsulation efficiency of hemoglobin was 40 wt %, and the hemoglobin content in the vesicles was 32 wt %. The CO-Hb encapsulated in the PLL-b-PPA vesicles was more stable than free CO-Hb under ambient conditions. In the presence of a O2 atmosphere, the CO-Hb in the vesicle could be converted into oxygen-binding hemoglobin (O2-Hb) under irradiation of visible light for 2 h. Therefore, the CO-Hb/PLL-b-PPA vesicles are expected to be used as red blood cell substitutes." @default.
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- W1989888276 date "2009-05-21" @default.
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- W1989888276 title "Oxygen Carrier Based on Hemoglobin/Poly(<scp>l</scp>-lysine)-<i>block</i>-poly(<scp>l</scp>-phenylalanine) Vesicles" @default.
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- W1989888276 doi "https://doi.org/10.1021/la901194k" @default.
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