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- W1989898265 abstract "Proglumide, a putative gastrin receptor antagonist, inhibited cholecystokinin (CCK)-stimulated amylase release and [3H]-2-deoxy-D-glucose uptake by isolated mouse pancreatic acini. Inhibition was reversible and competitive in nature with a KI of 0.7 mM. Proglumide also competitively inhibited the binding of 125I-CCK to its receptor in pancreas and brain; the KI for this interaction was 1.0 mM. In contrast, proglumide did not inhibit carbachol-stimulated amylase release, insulin-stimulated glucose transport and protein synthesis, or the binding of insulin to its receptors. Proglumide at 10 mM did, however, reduce both basal [3H]-2-deoxy-D-glucose uptake and [3H]-leucine incorporation into protein. We conclude that proglumide is a competitive and specific, albeit weak antagonist of CCK receptors. Higher concentrations of the drug may have other more nonspecific effects." @default.
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- W1989898265 date "1983-01-01" @default.
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- W1989898265 title "Effects of Proglumide on Pancreatic Acinar Cell Function" @default.
- W1989898265 doi "https://doi.org/10.1159/000198957" @default.
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