FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989904885> ?p ?o ?g. }

• W1989904885 endingPage "1271" @default.
• W1989904885 startingPage "1265" @default.
• W1989904885 abstract "The role of thrombolysis in hemodynamically stable patients with acute pulmonary embolism (PE) remains controversial. We performed a meta-analysis of randomized trials to assess the effect of thrombolysis in these patients.We searched MEDLINE and EMBASE for randomized studies comparing thrombolysis and heparin for the initial treatment of hemodynamically stable PE patients. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated. NNH to cause a major bleeding (MB) or an intracranial hemorrhage (ICH) and NNT to avoid one death were also calculated.Eleven studies (1833 patients) were included seven with rt-PA, three with tenecteplase and one with urokinase. Patients randomized to thrombolysis had a significant increased risk for MB (5.9% vs 1.9%; OR 2.83, 95% CI 1.68-4.76, I2 18.7%) and an increased risk for ICH (1.74% versus 0.6%; OR 2.36, 95% CI 0.98-5.71, I2 0%) and for fatal bleeding (1.3% versus 0.54%; OR 1.84, 95% CI 0.73-4.61, I2 0%). A not-significant reduction for all-cause death (1.74% vs 2.51%; OR 0.68, 95% CI 0.37-1.26, I2 0%) and a significant reduction for recurrent PE (1.1% vs 2.5%; OR 0.44, 95% CI 0.21-0.92, I2 0%) in favor of thrombolysis compared with heparin was found. NNH to cause a MB or an ICH were 27 and 91 patients, respectively. NNT to avoid one death was 125 patients.Due to increased risk for MB and ICH with no evidence of reduction in mortality, thrombolysis should not be used for most normotensive PE patients." @default.
• W1989904885 created "2016-06-24" @default.
• W1989904885 creator A5010238262 @default.
• W1989904885 creator A5054722205 @default.
• W1989904885 creator A5054783539 @default.
• W1989904885 creator A5064108429 @default.
• W1989904885 date "2014-12-01" @default.
• W1989904885 modified "2023-10-16" @default.
• W1989904885 title "Thrombolysis in hemodynamically stable patients with acute pulmonary embolism: A meta-analysis" @default.
• W1989904885 cites W1963915169 @default.
• W1989904885 cites W1971162409 @default.
• W1989904885 cites W1978243757 @default.
• W1989904885 cites W1986215651 @default.
• W1989904885 cites W1993443958 @default.
• W1989904885 cites W2003610429 @default.
• W1989904885 cites W2009344499 @default.
• W1989904885 cites W2011351675 @default.
• W1989904885 cites W2012614610 @default.
• W1989904885 cites W2013113528 @default.
• W1989904885 cites W2024687690 @default.
• W1989904885 cites W2027154734 @default.
• W1989904885 cites W2032284721 @default.
• W1989904885 cites W2032329819 @default.
• W1989904885 cites W2035753698 @default.
• W1989904885 cites W2038296306 @default.
• W1989904885 cites W2041176958 @default.
• W1989904885 cites W2041294294 @default.
• W1989904885 cites W2049490014 @default.
• W1989904885 cites W2053156671 @default.
• W1989904885 cites W2068868569 @default.
• W1989904885 cites W2071352385 @default.
• W1989904885 cites W2085984247 @default.
• W1989904885 cites W2092739280 @default.
• W1989904885 cites W2100487920 @default.
• W1989904885 cites W2107328434 @default.
• W1989904885 cites W2110112924 @default.
• W1989904885 cites W2110134277 @default.
• W1989904885 cites W2122779695 @default.
• W1989904885 cites W2123559921 @default.
• W1989904885 cites W2125435699 @default.
• W1989904885 cites W2125816252 @default.
• W1989904885 cites W2129593751 @default.
• W1989904885 cites W2152634120 @default.
• W1989904885 cites W2159007980 @default.
• W1989904885 cites W2164268628 @default.
• W1989904885 cites W2989714602 @default.
• W1989904885 doi "https://doi.org/10.1016/j.thromres.2014.10.004" @default.
• W1989904885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25457585" @default.
• W1989904885 hasPublicationYear "2014" @default.
• W1989904885 type Work @default.
• W1989904885 sameAs 1989904885 @default.
• W1989904885 citedByCount "43" @default.
• W1989904885 countsByYear W19899048852014 @default.
• W1989904885 countsByYear W19899048852015 @default.
• W1989904885 countsByYear W19899048852016 @default.
• W1989904885 countsByYear W19899048852017 @default.
• W1989904885 countsByYear W19899048852018 @default.
• W1989904885 countsByYear W19899048852019 @default.
• W1989904885 countsByYear W19899048852020 @default.
• W1989904885 countsByYear W19899048852021 @default.
• W1989904885 countsByYear W19899048852022 @default.
• W1989904885 countsByYear W19899048852023 @default.
• W1989904885 crossrefType "journal-article" @default.
• W1989904885 hasAuthorship W1989904885A5010238262 @default.
• W1989904885 hasAuthorship W1989904885A5054722205 @default.
• W1989904885 hasAuthorship W1989904885A5054783539 @default.
• W1989904885 hasAuthorship W1989904885A5064108429 @default.
• W1989904885 hasConcept C126322002 @default.
• W1989904885 hasConcept C141071460 @default.
• W1989904885 hasConcept C156957248 @default.
• W1989904885 hasConcept C168563851 @default.
• W1989904885 hasConcept C2776265017 @default.
• W1989904885 hasConcept C2776892390 @default.
• W1989904885 hasConcept C2779095551 @default.
• W1989904885 hasConcept C2779581417 @default.
• W1989904885 hasConcept C44249647 @default.
• W1989904885 hasConcept C500558357 @default.
• W1989904885 hasConcept C71924100 @default.
• W1989904885 hasConceptScore W1989904885C126322002 @default.
• W1989904885 hasConceptScore W1989904885C141071460 @default.
• W1989904885 hasConceptScore W1989904885C156957248 @default.
• W1989904885 hasConceptScore W1989904885C168563851 @default.
• W1989904885 hasConceptScore W1989904885C2776265017 @default.
• W1989904885 hasConceptScore W1989904885C2776892390 @default.
• W1989904885 hasConceptScore W1989904885C2779095551 @default.
• W1989904885 hasConceptScore W1989904885C2779581417 @default.
• W1989904885 hasConceptScore W1989904885C44249647 @default.
• W1989904885 hasConceptScore W1989904885C500558357 @default.
• W1989904885 hasConceptScore W1989904885C71924100 @default.
• W1989904885 hasIssue "6" @default.
• W1989904885 hasLocation W19899048851 @default.
• W1989904885 hasLocation W19899048852 @default.
• W1989904885 hasOpenAccess W1989904885 @default.
• W1989904885 hasPrimaryLocation W19899048851 @default.
• W1989904885 hasRelatedWork W165299973 @default.
• W1989904885 hasRelatedWork W1971880965 @default.
• W1989904885 hasRelatedWork W1980538268 @default.
• W1989904885 hasRelatedWork W2018814163 @default.

• next