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• W1989905855 abstract "Thrombospondin 1 is a secreted, trimeric glycoprotein that mediates interactions between cells and extracellular matrix and exhibits cell-specific effects on migration and proliferation. Recently, two additional thrombospondin genes (thrombospondin 2 and 3) have been identified. To study the functions of these proteins, we have used in situ hybridization and RNAse protection assays to compare the expression of the genes encoding thrombospondin 1, 2, and 3 during murine embryogenesis. Thrombospondin mRNAs were associated with ossification, neuronal organogenesis, and lung development, although transcripts were differentially expressed. Thrombospondin 1 was predominant from days 10 to 13. During this period, high but transient levels of expression were observed in the neural tube, head mesenchyme, and cardiac cushions. In contrast, a more constant level of thrombospondin 1 mRNA was apparent in resident megakaryocytes of the liver, as well as in circulating megakaryocytes; neither thrombospondin 2 nor 3 was detected in these cells. Thrombospondin 1 was also produced by cells of the developing kidney and gut. The expression of thrombospondin 2 was confined principally to organized connective tissue that included pericardium, pleura, perichondrium, periosteum, meninges, ligaments, and reticular dermis. Thrombospondin 2 was also produced by differentiating skeletal myoblasts and by cells of the kidney and gut. Moreover, high levels of expression were detected in blood vessels. Thrombospondin 3 mRNA was restricted to brain, cartilage, and lung. Although thrombospondin 1, 2, and 3 belong to a family of structurally related genes, the differences observed in the spatiotemporal distribution of the corresponding mRNAs indicate unique functions for these secreted proteins. © 1993 Wiley-Liss, Inc." @default.
• W1989905855 created "2016-06-24" @default.
• W1989905855 creator A5002256474 @default.
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• W1989905855 date "1993-05-01" @default.
• W1989905855 modified "2023-10-17" @default.
• W1989905855 title "Differential expression of thrombospondin 1, 2, and 3 during murine development" @default.
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• W1989905855 cites W1505957065 @default.
• W1989905855 cites W1512506249 @default.
• W1989905855 cites W1514093779 @default.
• W1989905855 cites W1519311536 @default.
• W1989905855 cites W1524114372 @default.
• W1989905855 cites W1537611160 @default.
• W1989905855 cites W1538283518 @default.
• W1989905855 cites W1550768646 @default.
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• W1989905855 cites W2082712298 @default.
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• W1989905855 doi "https://doi.org/10.1002/aja.1001970105" @default.
• W1989905855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8400410" @default.
• W1989905855 hasPublicationYear "1993" @default.
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