FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989933301> ?p ?o ?g. }

• W1989933301 endingPage "725" @default.
• W1989933301 startingPage "714" @default.
• W1989933301 abstract "Formamidopyrimidine-DNA glycosylase (Fpg; MutM) is a DNA repair enzyme widely distributed in bacteria. Fpg recognizes and excises oxidatively modified purines, 4,6-diamino-5-formamidopyrimidine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxoguanine (8-oxoG), with similar excision kinetics. It exhibits some lesser activity toward 8-oxoadenine. Fpg enzymes are also present in some plant and fungal species. The eukaryotic Fpg homologs exhibit little or no activity on DNA containing 8-oxoG, but they recognize and process its oxidation products, guanidinohydantoin (Gh) and spiroiminohydantoin (Sp). To date, several structures of bacterial Fpg enzymes unliganded or in complex with DNA containing a damaged base have been published but there is no structure of a eukaryotic Fpg. Here we describe the first crystal structure of a plant Fpg, Arabidopsis thaliana (AthFpg), unliganded and bound to DNA containing an abasic site analog, tetrahydrofuran (THF). Although AthFpg shares a common architecture with other Fpg glycosylases, it harbors a zincless finger, previously described in a subset of Nei enzymes, such as human NEIL1 and Mimivirus Nei1. Importantly the αF-β9/10 loop capping 8-oxoG in the active site of bacterial Fpg is very short in AthFpg. Deletion of a segment encompassing residues 213-229 in Escherichia coli Fpg (EcoFpg) and corresponding to the αF-β9/10 loop does not affect the recognition and removal of oxidatively damaged DNA base lesions, with the exception of 8-oxoG. Although the exact role of the loop remains to be further explored, it is now clear that this protein segment is specific to the processing of 8-oxoG." @default.
• W1989933301 created "2016-06-24" @default.
• W1989933301 creator A5002839723 @default.
• W1989933301 creator A5008302110 @default.
• W1989933301 creator A5012088953 @default.
• W1989933301 creator A5034691335 @default.
• W1989933301 creator A5051791551 @default.
• W1989933301 creator A5088798352 @default.
• W1989933301 date "2012-09-01" @default.
• W1989933301 modified "2023-10-10" @default.
• W1989933301 title "Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine" @default.
• W1989933301 cites W1447315841 @default.
• W1989933301 cites W1486488493 @default.
• W1989933301 cites W1494960307 @default.
• W1989933301 cites W1510358641 @default.
• W1989933301 cites W1539796472 @default.
• W1989933301 cites W1557175253 @default.
• W1989933301 cites W1614551514 @default.
• W1989933301 cites W1845321470 @default.
• W1989933301 cites W1965277349 @default.
• W1989933301 cites W1967194316 @default.
• W1989933301 cites W1967839472 @default.
• W1989933301 cites W1968894315 @default.
• W1989933301 cites W1970566518 @default.
• W1989933301 cites W1974066333 @default.
• W1989933301 cites W1976931021 @default.
• W1989933301 cites W1978096114 @default.
• W1989933301 cites W1979703710 @default.
• W1989933301 cites W1983898731 @default.
• W1989933301 cites W1984123187 @default.
• W1989933301 cites W1984290310 @default.
• W1989933301 cites W1985323804 @default.
• W1989933301 cites W1986670774 @default.
• W1989933301 cites W1993859324 @default.
• W1989933301 cites W1995017064 @default.
• W1989933301 cites W1995907499 @default.
• W1989933301 cites W1996194632 @default.
• W1989933301 cites W1997408199 @default.
• W1989933301 cites W1998139937 @default.
• W1989933301 cites W2016694525 @default.
• W1989933301 cites W2017421343 @default.
• W1989933301 cites W2022443227 @default.
• W1989933301 cites W2025346491 @default.
• W1989933301 cites W2028913243 @default.
• W1989933301 cites W2036681286 @default.
• W1989933301 cites W2042907868 @default.
• W1989933301 cites W2042937673 @default.
• W1989933301 cites W2050224588 @default.
• W1989933301 cites W2061919040 @default.
• W1989933301 cites W2063163055 @default.
• W1989933301 cites W2076271758 @default.
• W1989933301 cites W2082431983 @default.
• W1989933301 cites W2087290238 @default.
• W1989933301 cites W2090219305 @default.
• W1989933301 cites W2102713852 @default.
• W1989933301 cites W2104973213 @default.
• W1989933301 cites W2110893691 @default.
• W1989933301 cites W2112200653 @default.
• W1989933301 cites W2125534385 @default.
• W1989933301 cites W2127130852 @default.
• W1989933301 cites W2135632270 @default.
• W1989933301 cites W2144081223 @default.
• W1989933301 cites W2144998676 @default.
• W1989933301 cites W2149305996 @default.
• W1989933301 cites W2158714788 @default.
• W1989933301 cites W2158742644 @default.
• W1989933301 cites W2162800127 @default.
• W1989933301 cites W2412579716 @default.
• W1989933301 doi "https://doi.org/10.1016/j.dnarep.2012.06.004" @default.
• W1989933301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419285" @default.
• W1989933301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22789755" @default.
• W1989933301 hasPublicationYear "2012" @default.
• W1989933301 type Work @default.
• W1989933301 sameAs 1989933301 @default.
• W1989933301 citedByCount "47" @default.
• W1989933301 countsByYear W19899333012013 @default.
• W1989933301 countsByYear W19899333012014 @default.
• W1989933301 countsByYear W19899333012015 @default.
• W1989933301 countsByYear W19899333012016 @default.
• W1989933301 countsByYear W19899333012017 @default.
• W1989933301 countsByYear W19899333012018 @default.
• W1989933301 countsByYear W19899333012019 @default.
• W1989933301 countsByYear W19899333012020 @default.
• W1989933301 countsByYear W19899333012021 @default.
• W1989933301 countsByYear W19899333012022 @default.
• W1989933301 countsByYear W19899333012023 @default.
• W1989933301 crossrefType "journal-article" @default.
• W1989933301 hasAuthorship W1989933301A5002839723 @default.
• W1989933301 hasAuthorship W1989933301A5008302110 @default.
• W1989933301 hasAuthorship W1989933301A5012088953 @default.
• W1989933301 hasAuthorship W1989933301A5034691335 @default.
• W1989933301 hasAuthorship W1989933301A5051791551 @default.
• W1989933301 hasAuthorship W1989933301A5088798352 @default.
• W1989933301 hasBestOaLocation W19899333012 @default.
• W1989933301 hasConcept C1009745 @default.
• W1989933301 hasConcept C104451858 @default.
• W1989933301 hasConcept C134935766 @default.
• W1989933301 hasConcept C143425029 @default.

• next