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- W1989942781 abstract "O-linked β-N-Acetylglucosamine (O-GlcNAc) is a posttranslational modification that is catalyzed by O-GlcNAc transferase (Ogt) and found on a plethora of nuclear and cytosolic proteins in animals and plants. Studies in different model organisms revealed that while O-GlcNAc is required for selected processes in Caenorhabditis elegans and Drosophila, it has evolved to become required for cell viability in mice, and this has challenged investigations to identify cellular functions that critically require this modification in mammals. Nevertheless, a principal cellular process that engages O-GlcNAcylation in all of these species is the regulation of gene transcription. Here, we revisit several of the primary experimental observations that led to current models of how O-GlcNAcylation affects gene expression. In particular, we discuss the role of the stable association of Ogt with the transcription factors Hcf1 and Tet, the two main Ogt-interacting proteins in nuclei of mammalian cells. We also critically evaluate the evidence that specific residues on core histones, including serine 112 of histone 2B (H2B-S112), are O-GlcNAcylated in vivo and discuss possible physiological effects of these modifications. Finally, we review our understanding of the role of O-GlcNAcylation in Drosophila, where recent studies suggest that the developmental defects in Ogt mutants are all caused by lack of O-GlcNAcylation of a single transcriptional regulator, the Polycomb repressor protein Polyhomeotic (Ph). Collectively, this reexamination of the experimental evidence suggests that a number of recently propagated models about the role of O-GlcNAcylation in transcriptional control should be treated cautiously." @default.
- W1989942781 created "2016-06-24" @default.
- W1989942781 creator A5051816565 @default.
- W1989942781 creator A5071660959 @default.
- W1989942781 date "2015-04-18" @default.
- W1989942781 modified "2023-09-27" @default.
- W1989942781 title "A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin" @default.
- W1989942781 cites W1574290520 @default.
- W1989942781 cites W1601059079 @default.
- W1989942781 cites W1652316604 @default.
- W1989942781 cites W1896434730 @default.
- W1989942781 cites W1970709003 @default.
- W1989942781 cites W1970989906 @default.
- W1989942781 cites W1975518025 @default.
- W1989942781 cites W1975678442 @default.
- W1989942781 cites W1981659742 @default.
- W1989942781 cites W1987855481 @default.
- W1989942781 cites W1989561383 @default.
- W1989942781 cites W1990396035 @default.
- W1989942781 cites W1993627126 @default.
- W1989942781 cites W1994150489 @default.
- W1989942781 cites W1996786134 @default.
- W1989942781 cites W1997853510 @default.
- W1989942781 cites W2004373930 @default.
- W1989942781 cites W2006788765 @default.
- W1989942781 cites W2009853606 @default.
- W1989942781 cites W2012860378 @default.
- W1989942781 cites W2013020574 @default.
- W1989942781 cites W2016089890 @default.
- W1989942781 cites W2016408996 @default.
- W1989942781 cites W2021935830 @default.
- W1989942781 cites W2023620203 @default.
- W1989942781 cites W2025092145 @default.
- W1989942781 cites W2026898742 @default.
- W1989942781 cites W2031087463 @default.
- W1989942781 cites W2031522618 @default.
- W1989942781 cites W2033832954 @default.
- W1989942781 cites W2034827327 @default.
- W1989942781 cites W2036574186 @default.
- W1989942781 cites W2041967294 @default.
- W1989942781 cites W2042233932 @default.
- W1989942781 cites W2042584499 @default.
- W1989942781 cites W2043422368 @default.
- W1989942781 cites W2043485161 @default.
- W1989942781 cites W2045407836 @default.
- W1989942781 cites W2048523500 @default.
- W1989942781 cites W2050079285 @default.
- W1989942781 cites W2050149304 @default.
- W1989942781 cites W2050575492 @default.
- W1989942781 cites W2051948190 @default.
- W1989942781 cites W2052135200 @default.
- W1989942781 cites W2053564705 @default.
- W1989942781 cites W2057513702 @default.
- W1989942781 cites W2061011762 @default.
- W1989942781 cites W2063071041 @default.
- W1989942781 cites W2065955997 @default.
- W1989942781 cites W2067380629 @default.
- W1989942781 cites W2068050716 @default.
- W1989942781 cites W2068470826 @default.
- W1989942781 cites W2069052453 @default.
- W1989942781 cites W2070991372 @default.
- W1989942781 cites W2071445941 @default.
- W1989942781 cites W2071520055 @default.
- W1989942781 cites W2072574932 @default.
- W1989942781 cites W2074146315 @default.
- W1989942781 cites W2074437836 @default.
- W1989942781 cites W2075375055 @default.
- W1989942781 cites W2076558019 @default.
- W1989942781 cites W2077561581 @default.
- W1989942781 cites W2077903723 @default.
- W1989942781 cites W2082638557 @default.
- W1989942781 cites W2083232319 @default.
- W1989942781 cites W2085656281 @default.
- W1989942781 cites W2086569998 @default.
- W1989942781 cites W2088708165 @default.
- W1989942781 cites W2089315523 @default.
- W1989942781 cites W2091914853 @default.
- W1989942781 cites W2093090845 @default.
- W1989942781 cites W2095491514 @default.
- W1989942781 cites W2096592893 @default.
- W1989942781 cites W2099766227 @default.
- W1989942781 cites W2101298061 @default.
- W1989942781 cites W2107279676 @default.
- W1989942781 cites W2107301621 @default.
- W1989942781 cites W2107601138 @default.
- W1989942781 cites W2109361919 @default.
- W1989942781 cites W2112965309 @default.
- W1989942781 cites W2120628024 @default.
- W1989942781 cites W2123419812 @default.
- W1989942781 cites W2125391496 @default.
- W1989942781 cites W2127015328 @default.
- W1989942781 cites W2129172597 @default.
- W1989942781 cites W2137404591 @default.
- W1989942781 cites W2138867046 @default.
- W1989942781 cites W2140409722 @default.
- W1989942781 cites W2147231609 @default.
- W1989942781 cites W2147524392 @default.
- W1989942781 cites W2149202312 @default.