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- W1989953805 abstract "We hypothesized specific growth factors are increased in the elbow capsules of patients with post traumatic elbow contractures. A model of surgically induced joint contracture in rabbit knees was developed to study the growth factor expression in joint contractures. This study demonstrates this model mimics the human condition and analyzes how the growth factor levels decrease with time in rabbit knees with contractures. Reverse transcription polymerase chain reaction was used to measure mRNA levels of transforming growth factor-β1, connective tissue growth factor, ED-A of fibronectin, and α-smooth muscle actin normalized to a housekeeping gene, glyceraldehyde-3-phosphate dehydrogenase. In the joint capsules of patients with elbow contractures, mRNA levels were increased for transforming growth factor-β1, connective tissue growth factor, and α-smooth muscle actin. In the joint capsules of rabbit knees with contractures, mRNA levels were increased for transforming growth factor-β1, connective tissue growth factor, ED-A of fibronectin, and α-smooth muscle actin. The mRNA levels for transforming growth factor-β1, connective tissue growth factor, and α-smooth muscle actin decreased with time in rabbit knees. The elevated levels of these myofibroblast upregulators and fibrogenic growth factors could explain the previously reported increase in myofibroblasts and collagen mRNA levels. The rabbit knee model correlated well with the human post traumatic elbow contractures. Level of Evidence: Level II, prospective comparative study. See the Guidelines for Authors for a complete description of levels of evidence." @default.
- W1989953805 created "2016-06-24" @default.
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- W1989953805 date "2007-03-01" @default.
- W1989953805 modified "2023-10-16" @default.
- W1989953805 title "Myofibroblast Upregulators are Elevated in Joint Capsules in Posttraumatic Contractures" @default.
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- W1989953805 doi "https://doi.org/10.1097/blo.0b013e3180312c01" @default.
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