FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989957765> ?p ?o ?g. }

• W1989957765 endingPage "2917" @default.
• W1989957765 startingPage "2906" @default.
• W1989957765 abstract "Endothelial cells (ECs) in blood vessels under formation are stabilized by the recruitment of pericytes, both in normal tissues and during angiogenesis in pathologic situations, including neoplasia. In the tumor vasculature, besides supporting the functionality of blood flow, pericytes protect ECs from antiangiogenic therapies, and have thus been implicated in clinical resistance to vascular targeting drugs. However, the molecular nature of the crosstalk between pericytes and ECs is largely unchartered. Herein, we identified pericyte-induced survival signals in ECs by isolation of vascular fragments derived from tumors that had been genetically or pharmacologically engineered to be either pericyte-rich or pericyte-poor. Pericytes induced the antiapoptotic protein Bcl-w in tumor ECs both in vivo and in vitro, thereby conveying protection from cytotoxic damage. The pericyte-dependent survival signaling in ECs was consequential to enforcement of an autocrine loop involving VEGF-A expression in ECs. Through molecular and functional studies, we delineated a signal transduction pathway in ECs downstream of integrin α(v) involving activation of NF-κB as the initiating event of the protective crosstalk from pericytes. Our elucidation of pericyte-derived pro-survival signaling in tumor ECs has potentially important implications for clinical development of antiangiogenic drugs, and suggests new therapeutic targets for rational multitargeting of cancer." @default.
• W1989957765 created "2016-06-24" @default.
• W1989957765 creator A5007537368 @default.
• W1989957765 creator A5021877980 @default.
• W1989957765 creator A5024761643 @default.
• W1989957765 creator A5059726837 @default.
• W1989957765 creator A5062628170 @default.
• W1989957765 date "2011-09-08" @default.
• W1989957765 modified "2023-10-12" @default.
• W1989957765 title "Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression" @default.
• W1989957765 cites W103592546 @default.
• W1989957765 cites W1967830128 @default.
• W1989957765 cites W1973358829 @default.
• W1989957765 cites W1977999028 @default.
• W1989957765 cites W1987003519 @default.
• W1989957765 cites W1993866602 @default.
• W1989957765 cites W1999966467 @default.
• W1989957765 cites W2002495134 @default.
• W1989957765 cites W2009673528 @default.
• W1989957765 cites W2011403734 @default.
• W1989957765 cites W2028466368 @default.
• W1989957765 cites W2029883816 @default.
• W1989957765 cites W2033049522 @default.
• W1989957765 cites W2034548257 @default.
• W1989957765 cites W2039313723 @default.
• W1989957765 cites W2056840154 @default.
• W1989957765 cites W2057584928 @default.
• W1989957765 cites W2062266880 @default.
• W1989957765 cites W2070108397 @default.
• W1989957765 cites W2089723533 @default.
• W1989957765 cites W2089956125 @default.
• W1989957765 cites W2100669312 @default.
• W1989957765 cites W2101947487 @default.
• W1989957765 cites W2112251383 @default.
• W1989957765 cites W2112940666 @default.
• W1989957765 cites W2114834794 @default.
• W1989957765 cites W2115390024 @default.
• W1989957765 cites W2126712079 @default.
• W1989957765 cites W2131393213 @default.
• W1989957765 cites W2134771161 @default.
• W1989957765 cites W2140088548 @default.
• W1989957765 cites W2149456801 @default.
• W1989957765 cites W2149806683 @default.
• W1989957765 cites W2151637779 @default.
• W1989957765 cites W2159593598 @default.
• W1989957765 cites W2162525969 @default.
• W1989957765 cites W2163011434 @default.
• W1989957765 cites W2170174828 @default.
• W1989957765 cites W2171715330 @default.
• W1989957765 cites W2314325548 @default.
• W1989957765 cites W4247506353 @default.
• W1989957765 cites W4252851641 @default.
• W1989957765 cites W4253705647 @default.
• W1989957765 doi "https://doi.org/10.1182/blood-2011-01-331694" @default.
• W1989957765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172806" @default.
• W1989957765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778339" @default.
• W1989957765 hasPublicationYear "2011" @default.
• W1989957765 type Work @default.
• W1989957765 sameAs 1989957765 @default.
• W1989957765 citedByCount "250" @default.
• W1989957765 countsByYear W19899577652012 @default.
• W1989957765 countsByYear W19899577652013 @default.
• W1989957765 countsByYear W19899577652014 @default.
• W1989957765 countsByYear W19899577652015 @default.
• W1989957765 countsByYear W19899577652016 @default.
• W1989957765 countsByYear W19899577652017 @default.
• W1989957765 countsByYear W19899577652018 @default.
• W1989957765 countsByYear W19899577652019 @default.
• W1989957765 countsByYear W19899577652020 @default.
• W1989957765 countsByYear W19899577652021 @default.
• W1989957765 countsByYear W19899577652022 @default.
• W1989957765 countsByYear W19899577652023 @default.
• W1989957765 crossrefType "journal-article" @default.
• W1989957765 hasAuthorship W1989957765A5007537368 @default.
• W1989957765 hasAuthorship W1989957765A5021877980 @default.
• W1989957765 hasAuthorship W1989957765A5024761643 @default.
• W1989957765 hasAuthorship W1989957765A5059726837 @default.
• W1989957765 hasAuthorship W1989957765A5062628170 @default.
• W1989957765 hasBestOaLocation W19899577652 @default.
• W1989957765 hasConcept C111758988 @default.
• W1989957765 hasConcept C120665830 @default.
• W1989957765 hasConcept C121332964 @default.
• W1989957765 hasConcept C123012128 @default.
• W1989957765 hasConcept C128240485 @default.
• W1989957765 hasConcept C169822122 @default.
• W1989957765 hasConcept C170493617 @default.
• W1989957765 hasConcept C202751555 @default.
• W1989957765 hasConcept C2780394083 @default.
• W1989957765 hasConcept C2780427682 @default.
• W1989957765 hasConcept C502942594 @default.
• W1989957765 hasConcept C54355233 @default.
• W1989957765 hasConcept C62478195 @default.
• W1989957765 hasConcept C7876069 @default.
• W1989957765 hasConcept C81885089 @default.
• W1989957765 hasConcept C86803240 @default.
• W1989957765 hasConcept C95444343 @default.
• W1989957765 hasConceptScore W1989957765C111758988 @default.
• W1989957765 hasConceptScore W1989957765C120665830 @default.

• next