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- W1989968791 abstract "More than 10 years after publication of the first randomised trial to assess drug-eluting stents (DES) in patients with coronary artery disease, 1 Morice MC Serruys PW Sousa JE et al. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med. 2002; 346: 1773-1780 Crossref PubMed Scopus (3870) Google Scholar many studies have helped to clarify the advantages and limitations of first-generation DES. Despite having high antirestenotic efficacy in the first year after implantation, first-generation DES are associated with a delayed healing effect, leading to increased risk of late stent thrombosis 2 Daemen J Wenaweser P Tsuchida K et al. Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet. 2007; 369: 667-678 Summary Full Text Full Text PDF PubMed Scopus (1579) Google Scholar and a decrease in antirestenotic efficacy over time, 3 Byrne RA Iijima R Mehilli J et al. Durability of antirestenotic efficacy in drug-eluting stents with and without permanent polymer. JACC Cardiovasc Interv. 2009; 2: 291-299 Summary Full Text Full Text PDF Scopus (154) Google Scholar which has affected acceptance and stimulated the search for better successors. Polymers have become the main focus of the drawbacks associated with first-generation DES. For this reason, research efforts have been directed at improvement in biocompatibility of permanent polymers, the use of biodegradable polymer coatings that disappear over time, and the development of DES completely bereft of polymer. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trialAt 1 year follow-up, the biodegradable polymer biolimus-eluting Nobori stent did not improve clinical results compared with a first-generation sirolimus-eluting stent. We will need to obtain long-term data before we can make recommendations for the role of this biolimus-eluting stent in routine clinical practice. Full-Text PDF" @default.
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- W1989968791 date "2013-02-01" @default.
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- W1989968791 title "SORT OUT V: a new episode in the DES wars" @default.
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