FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989969076> ?p ?o ?g. }

• W1989969076 endingPage "451" @default.
• W1989969076 startingPage "443" @default.
• W1989969076 abstract "We recently reported the results of a genome-wide association study (GWAS) of schizophrenia in the Japanese population. In that study, a single nucleotide polymorphism (SNP) (rs3106653) in the KCNJ3 (potassium inwardly rectifying channel, subfamily J, member 3) gene located at 2q24.1 showed association with schizophrenia in two independent sample sets. KCNJ3, also termed GIRK1 or Kir3.1, is a member of the G protein-activated inwardly rectifying K(+) channel (GIRK) group. GIRKs are widely distributed in the brain and play an important role in regulating neural excitability through the activation of various G protein-coupled receptors. In this study, we set out to examine this association using a different population. We first performed a gene-centric association study of the KCNJ3 gene, by genotyping 38 tagSNPs in the Chinese population. We detected nine SNPs that displayed significant association with schizophrenia (lowest P = 0.0016 for rs3106658, Global significance = 0.036). The initial marker SNP (rs3106653) examined in our prior GWAS in the Japanese population also showed nominally significant association in the Chinese population (P = 0.028). Next, we analyzed transcript levels in the dorsolateral prefrontal cortex of postmortem brains from patients with schizophrenia and bipolar disorder and from healthy controls, using real-time quantitative RT-PCR. We found significantly lower KCNJ3 expression in postmortem brains from schizophrenic and bipolar patients compared with controls. These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the channelopathy theory of psychiatric illnesses." @default.
• W1989969076 created "2016-06-24" @default.
• W1989969076 creator A5008400314 @default.
• W1989969076 creator A5010471231 @default.
• W1989969076 creator A5034240719 @default.
• W1989969076 creator A5061632695 @default.
• W1989969076 creator A5064366813 @default.
• W1989969076 creator A5072253152 @default.
• W1989969076 creator A5085932011 @default.
• W1989969076 date "2011-09-17" @default.
• W1989969076 modified "2023-10-08" @default.
• W1989969076 title "Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population" @default.
• W1989969076 cites W1533708729 @default.
• W1989969076 cites W1560053015 @default.
• W1989969076 cites W1569781386 @default.
• W1989969076 cites W1975224317 @default.
• W1989969076 cites W1982155128 @default.
• W1989969076 cites W1992836821 @default.
• W1989969076 cites W1995952358 @default.
• W1989969076 cites W2004168702 @default.
• W1989969076 cites W2010333320 @default.
• W1989969076 cites W2013616449 @default.
• W1989969076 cites W2015408724 @default.
• W1989969076 cites W2020237866 @default.
• W1989969076 cites W2020425432 @default.
• W1989969076 cites W2020645864 @default.
• W1989969076 cites W2021377987 @default.
• W1989969076 cites W2026494312 @default.
• W1989969076 cites W2028360988 @default.
• W1989969076 cites W2028403185 @default.
• W1989969076 cites W2029220352 @default.
• W1989969076 cites W2048499810 @default.
• W1989969076 cites W2050546628 @default.
• W1989969076 cites W2050917547 @default.
• W1989969076 cites W2053941511 @default.
• W1989969076 cites W2058606373 @default.
• W1989969076 cites W2059668014 @default.
• W1989969076 cites W2063366770 @default.
• W1989969076 cites W2074698764 @default.
• W1989969076 cites W2076824470 @default.
• W1989969076 cites W2083283348 @default.
• W1989969076 cites W2087139802 @default.
• W1989969076 cites W2094137970 @default.
• W1989969076 cites W2096035098 @default.
• W1989969076 cites W2107144297 @default.
• W1989969076 cites W2112810336 @default.
• W1989969076 cites W2115588325 @default.
• W1989969076 cites W2115600578 @default.
• W1989969076 cites W2121926780 @default.
• W1989969076 cites W2125713710 @default.
• W1989969076 cites W2138098510 @default.
• W1989969076 cites W2141611690 @default.
• W1989969076 cites W2144329586 @default.
• W1989969076 cites W2152600990 @default.
• W1989969076 cites W2152664025 @default.
• W1989969076 cites W2159016014 @default.
• W1989969076 cites W2161227647 @default.
• W1989969076 cites W2162212014 @default.
• W1989969076 cites W2162530578 @default.
• W1989969076 cites W2165451664 @default.
• W1989969076 cites W2194134614 @default.
• W1989969076 cites W2290802694 @default.
• W1989969076 doi "https://doi.org/10.1007/s00439-011-1089-3" @default.
• W1989969076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3277701" @default.
• W1989969076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21927946" @default.
• W1989969076 hasPublicationYear "2011" @default.
• W1989969076 type Work @default.
• W1989969076 sameAs 1989969076 @default.
• W1989969076 citedByCount "45" @default.
• W1989969076 countsByYear W19899690762012 @default.
• W1989969076 countsByYear W19899690762013 @default.
• W1989969076 countsByYear W19899690762014 @default.
• W1989969076 countsByYear W19899690762015 @default.
• W1989969076 countsByYear W19899690762016 @default.
• W1989969076 countsByYear W19899690762017 @default.
• W1989969076 countsByYear W19899690762018 @default.
• W1989969076 countsByYear W19899690762020 @default.
• W1989969076 countsByYear W19899690762021 @default.
• W1989969076 countsByYear W19899690762022 @default.
• W1989969076 countsByYear W19899690762023 @default.
• W1989969076 crossrefType "journal-article" @default.
• W1989969076 hasAuthorship W1989969076A5008400314 @default.
• W1989969076 hasAuthorship W1989969076A5010471231 @default.
• W1989969076 hasAuthorship W1989969076A5034240719 @default.
• W1989969076 hasAuthorship W1989969076A5061632695 @default.
• W1989969076 hasAuthorship W1989969076A5064366813 @default.
• W1989969076 hasAuthorship W1989969076A5072253152 @default.
• W1989969076 hasAuthorship W1989969076A5085932011 @default.
• W1989969076 hasBestOaLocation W19899690761 @default.
• W1989969076 hasConcept C104317684 @default.
• W1989969076 hasConcept C106208931 @default.
• W1989969076 hasConcept C118552586 @default.
• W1989969076 hasConcept C135763542 @default.
• W1989969076 hasConcept C139275648 @default.
• W1989969076 hasConcept C153209595 @default.
• W1989969076 hasConcept C169760540 @default.
• W1989969076 hasConcept C169900460 @default.
• W1989969076 hasConcept C186413461 @default.

• next