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• W1989971736 abstract "Ergothioneine (ET) is an unusual sulfur-containing derivative of the amino acid, histidine, which is derived exclusively through the diet. Although ET was isolated a century ago, its physiologic function has not been clearly established. Recently, a highly specific transporter for ET (ETT) was identified in mammalian tissues, which explains abundant tissue levels of ET and implies a physiologic role. Using RNA interference, we depleted cells of its transporter. Cells lacking ETT are more susceptible to oxidative stress, resulting in increased mitochondrial DNA damage, protein oxidation and lipid peroxidation. ETT is concentrated in mitochondria, suggesting a specific role in protecting mitochondrial components such as DNA from oxidative damage associated with mitochondrial generation of superoxide. In combating cytotoxic effects of pyrogallol, a known superoxide generator, ET is as potent as glutathione. Because of its dietary origin and the toxicity associated with its depletion, ET may represent a new vitamin whose physiologic roles include antioxidant cytoprotection." @default.
• W1989971736 created "2016-06-24" @default.
• W1989971736 creator A5006367625 @default.
• W1989971736 creator A5020208893 @default.
• W1989971736 date "2009-11-13" @default.
• W1989971736 modified "2023-10-12" @default.
• W1989971736 title "The unusual amino acid L-ergothioneine is a physiologic cytoprotectant" @default.
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• W1989971736 doi "https://doi.org/10.1038/cdd.2009.163" @default.
• W1989971736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2885499" @default.
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