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• W1989981444 abstract "Stringent developmental transcription requires multiple transcription factor (TF) binding sites, cell-specific expression of signaling molecules, TFs and co-regulators and appropriate chromatin structure. During B-lymphopoiesis, human Complement receptor 2 (CR2/CD21) is detected on immature and mature B cells but not on B cell precursors and plasma cells. We examined cell- and stage-specific human CR2 gene regulation using cell lines modeling B-lymphopoiesis. Chromatin accessibility assays revealed a region between -409 and -262 with enhanced accessibility in mature B cells and pre-B cells, compared to either non-lymphoid or plasma cell-types, however, accessibility near the transcription start site (TSS) was elevated only in CR2-expressing B cells. A correlation between histone acetylation and CR2 expression was observed, while histone H3K4 dimethylation was enriched near the TSS in both CR2-expressing B cells and non-expressing pre-B cells. Candidate sites within the CR2 promoter were identified which could regulate chromatin, including a matrix attachment region associated with CDP, SATB1/BRIGHT and CEBP-beta sites as well as two CBF1 sites. ChIP assays verified that both CBF1 and C/EBP-beta bind the CR2 promoter in B cells raising the possibility that these factors facilitate or respond to alterations in chromatin structure to control the timing and/or level of CR2 transcription." @default.
• W1989981444 created "2016-06-24" @default.
• W1989981444 creator A5014046203 @default.
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• W1989981444 creator A5047156111 @default.
• W1989981444 creator A5053789063 @default.
• W1989981444 date "2009-08-01" @default.
• W1989981444 modified "2023-10-16" @default.
• W1989981444 title "Cell- and stage-specific chromatin structure across the Complement receptor 2 (CR2/CD21) promoter coincide with CBF1 and C/EBP-beta binding in B cells." @default.
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• W1989981444 doi "https://doi.org/10.1016/j.molimm.2009.05.001" @default.
• W1989981444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19487031" @default.
• W1989981444 hasPublicationYear "2009" @default.
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