Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989982912> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1989982912 endingPage "238" @default.
- W1989982912 startingPage "232" @default.
- W1989982912 abstract "We describe the amino acid substitutions of albumins Sondrio and Paris 2, two slow moving variants of human serum albumin, which show an identical electrophoretic mobility on cellulose acetate at three different pH values. These variants have been found in several instances in a wide geographic area including Northern Italy and France. Both alloalbumins were isolated from the sera of heterozygous subjects. Isoelectric focusing analysis of CNBr fragments from the purified variants allowed us to localize the mutation of albumin Sondrio in fragment CNBr V (residues 330-446) and that of albumin Paris 2 in CNBr VII (residues 549-585). Sequential analysis of the variant CNBr VII established the molecular defect of albumin Paris 2 as 563 Asp----Asn. Fragments CNBr V from normal and Sondrio albumins were isolated on a preparative scale and subjected to tryptic and V8 proteinase digestion. Sequence determination of the abnormal tryptic and V8 peptides revealed that the variant arises from the substitution of glutamic acid 333 by lysine. Thus, a +1 change in the C-terminal region of the albumin molecule produces a variant with the same electrophoretic mobility as an alloalbumin with a +2 substitution in the central domain, suggesting a higher degree of exposure to the solvent of the C-terminal tailpiece. Both amino acid substitutions are consistent with a G----A transition in the first position of the corresponding codon in the structural gene." @default.
- W1989982912 created "2016-06-24" @default.
- W1989982912 creator A5009846321 @default.
- W1989982912 creator A5045955449 @default.
- W1989982912 creator A5047687699 @default.
- W1989982912 creator A5060562600 @default.
- W1989982912 creator A5062549444 @default.
- W1989982912 creator A5069522205 @default.
- W1989982912 creator A5089589427 @default.
- W1989982912 date "1992-03-01" @default.
- W1989982912 modified "2023-09-27" @default.
- W1989982912 title "Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions" @default.
- W1989982912 cites W1020566274 @default.
- W1989982912 cites W1494228633 @default.
- W1989982912 cites W1499449111 @default.
- W1989982912 cites W1501912047 @default.
- W1989982912 cites W1546437332 @default.
- W1989982912 cites W1587117096 @default.
- W1989982912 cites W184399086 @default.
- W1989982912 cites W1969084361 @default.
- W1989982912 cites W1979569049 @default.
- W1989982912 cites W1981117347 @default.
- W1989982912 cites W1984762687 @default.
- W1989982912 cites W1995953749 @default.
- W1989982912 cites W2031573483 @default.
- W1989982912 cites W2042391719 @default.
- W1989982912 cites W2050591791 @default.
- W1989982912 cites W2055048115 @default.
- W1989982912 cites W2076509471 @default.
- W1989982912 cites W2210267600 @default.
- W1989982912 doi "https://doi.org/10.1016/0167-4838(92)90207-t" @default.
- W1989982912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1347703" @default.
- W1989982912 hasPublicationYear "1992" @default.
- W1989982912 type Work @default.
- W1989982912 sameAs 1989982912 @default.
- W1989982912 citedByCount "16" @default.
- W1989982912 countsByYear W19899829122012 @default.
- W1989982912 countsByYear W19899829122013 @default.
- W1989982912 crossrefType "journal-article" @default.
- W1989982912 hasAuthorship W1989982912A5009846321 @default.
- W1989982912 hasAuthorship W1989982912A5045955449 @default.
- W1989982912 hasAuthorship W1989982912A5047687699 @default.
- W1989982912 hasAuthorship W1989982912A5060562600 @default.
- W1989982912 hasAuthorship W1989982912A5062549444 @default.
- W1989982912 hasAuthorship W1989982912A5069522205 @default.
- W1989982912 hasAuthorship W1989982912A5089589427 @default.
- W1989982912 hasConcept C104317684 @default.
- W1989982912 hasConcept C153911025 @default.
- W1989982912 hasConcept C167625842 @default.
- W1989982912 hasConcept C181199279 @default.
- W1989982912 hasConcept C185592680 @default.
- W1989982912 hasConcept C194232998 @default.
- W1989982912 hasConcept C2776016237 @default.
- W1989982912 hasConcept C2776125364 @default.
- W1989982912 hasConcept C2994376932 @default.
- W1989982912 hasConcept C40250595 @default.
- W1989982912 hasConcept C50476208 @default.
- W1989982912 hasConcept C515207424 @default.
- W1989982912 hasConcept C55493867 @default.
- W1989982912 hasConcept C86803240 @default.
- W1989982912 hasConceptScore W1989982912C104317684 @default.
- W1989982912 hasConceptScore W1989982912C153911025 @default.
- W1989982912 hasConceptScore W1989982912C167625842 @default.
- W1989982912 hasConceptScore W1989982912C181199279 @default.
- W1989982912 hasConceptScore W1989982912C185592680 @default.
- W1989982912 hasConceptScore W1989982912C194232998 @default.
- W1989982912 hasConceptScore W1989982912C2776016237 @default.
- W1989982912 hasConceptScore W1989982912C2776125364 @default.
- W1989982912 hasConceptScore W1989982912C2994376932 @default.
- W1989982912 hasConceptScore W1989982912C40250595 @default.
- W1989982912 hasConceptScore W1989982912C50476208 @default.
- W1989982912 hasConceptScore W1989982912C515207424 @default.
- W1989982912 hasConceptScore W1989982912C55493867 @default.
- W1989982912 hasConceptScore W1989982912C86803240 @default.
- W1989982912 hasIssue "3" @default.
- W1989982912 hasLocation W19899829121 @default.
- W1989982912 hasLocation W19899829122 @default.
- W1989982912 hasOpenAccess W1989982912 @default.
- W1989982912 hasPrimaryLocation W19899829121 @default.
- W1989982912 hasRelatedWork W1974824538 @default.
- W1989982912 hasRelatedWork W1989982912 @default.
- W1989982912 hasRelatedWork W1993795649 @default.
- W1989982912 hasRelatedWork W2059998429 @default.
- W1989982912 hasRelatedWork W2073495827 @default.
- W1989982912 hasRelatedWork W2081940762 @default.
- W1989982912 hasRelatedWork W2125428182 @default.
- W1989982912 hasRelatedWork W2422865072 @default.
- W1989982912 hasRelatedWork W2970803107 @default.
- W1989982912 hasRelatedWork W3022776727 @default.
- W1989982912 hasVolume "1119" @default.
- W1989982912 isParatext "false" @default.
- W1989982912 isRetracted "false" @default.
- W1989982912 magId "1989982912" @default.
- W1989982912 workType "article" @default.