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- W1989989128 abstract "A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI50, 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25−180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38)." @default.
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- W1989989128 date "2000-12-05" @default.
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- W1989989128 title "Strychnogucines A and B, Two New Antiplasmodial Bisindole Alkaloids from <i>Strychnos </i><i>icaja</i>" @default.
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- W1989989128 doi "https://doi.org/10.1021/np000285t" @default.
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